Novel cyclic azobenzene-containing vesicles: photo/reductant responsiveness and potential applications in colon disease treatment
Novel cyclic azobenzene-containing vesicles: photo/reductant responsiveness and potential applications in colon disease treatment
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新型含环状偶氮苯的囊泡：光/还原剂反应性及其在结肠疾病治疗中的潜在应用
DOI：
10.1039/c6ra12751g
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Xiulin Zhu
中科院分区：
文献类型：
--
作者：
Jinjie Lu;Feng Zhou;Lishan Li;Zhengbiao Zhang;Fenghua Meng;Nianchen Zhou;Xiulin Zhu
在两亲共聚物的疏水链段中选择了环状偶氮苯作为侧链，构建了具有光和还原剂双重响应性的新型纳米粒子。为了研究环状偶氮苯结构对性能的影响，我们还合成了一种含有线型偶氮苯单元的两亲性共聚物的类似物。在pH=7.4的PB溶液中，两种含环状偶氮苯的两亲性共聚物(PEG45-b-PCAzo17)和线型偶氮苯悬浮体(PEG45-b-PLAzo19)组装成稳定的囊泡，并对紫外光和二硫代硫酸盐衍生物表现出独特的双重敏感性。我们考察了两种共聚物得到的囊泡对尼罗红(NR)或阿霉素(DOX)的包封率和释放率的差异。与PEG45-b-PLAzo19形成的囊泡相比，PEG45-b-PCAzo17形成的囊泡具有更高的载药量和更好的NR荧光变化可逆性，同时没有检测到尼罗红分子的破坏和泄漏。此外，在Na2S2O4的还原作用下，含CaO的囊泡表现出较高的释放率和较大的DOX分子释放量。由于二亚硫酸盐可以作为偶氮还原酶的模拟物，与环偶氮苯形成的两亲性共聚物作为一种治疗结肠病的药物载体显示出了极具竞争力的性能。
A cyclic azobenzene was chosen as a pendant in the hydrophobic segments of amphiphilic copolymers, and novel nanoparticles were constructed with dual photo and reductant responsiveness. To investigate the topological effects of the cyclic azobenzene architecture on the properties, an analogue of the amphiphilic copolymer with linear azobenzene units was also synthesized. Two kinds of amphiphilic copolymers with cyclic azobenzene (PEG45-b-PCAzo17) and linear azobenzene pendants (PEG45-b-PLAzo19) assembled into stable vesicles in PB solution (pH = 7.4) and also show unique dual sensitivities to ultraviolet radiation and dithionate derivatives. We have investigated the differences of the vesicles obtained from the two kinds of copolymers in the encapsulation and release of Nile Red (NR) or doxorubicin (DOX). The vesicles formed by PEG45-b-PCAzo17 exhibited higher drug loading content and better reversibility of NR fluorescence variation under alternating irradiation with UV/Vis light than those formed by PEG45-b-PLAzo19; meanwhile, neither disruption of the vesicles nor leakage of Nile Red molecules was detected. Moreover, the CAzo-containing vesicles showed a higher release rate and larger release amount of DOX molecules from the membrane under the reduction of Na2S2O4. Because dithionites can act as a mimic of azoreductase, the amphiphilic copolymer with cyclic azobenzene revealed competitive performance as a drug carrier for colon disease treatment.
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