Predictors of Comorbid Conditions in Women Who Carry an FMR1 Premutation.
Predictors of Comorbid Conditions in Women Who Carry an FMR1 Premutation.
复制标题
DOI：
10.3389/fpsyt.2021.715922
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Sherman SL
中科院分区：
文献类型：
--
作者：
Allen EG;Charen K;Hipp HS;Shubeck L;Amin A;He W;Hunter JE;Shelly KE;Sherman SL
目的：携带FMR 1前突变（PM）的女性可能会经历两种成熟的PM相关疾病：脆性X相关原发性卵巢功能不全（FXPOI，影响约20-30%的携带者）和脆性X相关震颤-共济失调综合征（FXTAS，影响约6-15%的携带者）;然而，新出现的证据表明，这些女性中的一些人经历了FXPOI和FXTAS之外的复杂健康状况。研究方法：为了更好地了解这些合并症的预测因素，我们收集了413名携带FMR 1 PM的女性的自我报告病史。结果：至少9%的妇女报告了22种健康状况。在探索性分析中，在逻辑回归模型中对每种共病状况的12个变量进行了测试，包括人口统计学变量、环境变量、PM相关因素以及对抑郁和/或焦虑的认可。超过一半的共病研究与自我报告有焦虑的女性有关。年龄、吸烟、体重指数（BMI）和抑郁也是特定共病的重要预测变量。结论：年龄、吸烟和BMI与分析的共病状况的子集显著相关。重要的是，抑郁或焦虑也与许多共病健康状况显著相关。这项工作突出了一些与FMR 1 PM女性复杂健康状况相关的可改变因素。
Purpose: Women who carry an FMR1 premutation (PM) can experience two well-established PM-associated disorders: fragile X-associated primary ovarian insufficiency (FXPOI, affects ~20–30% carriers) and fragile X-associated tremor-ataxia syndrome (FXTAS, affects ~6–15% carriers); however, emerging evidence indicates that some of these women experience complex health profiles beyond FXPOI and FXTAS. Methods: In an effort to better understand predictors for these comorbid conditions, we collected self-reported medical histories on 413 women who carry an FMR1 PM. Results: There were 22 health conditions reported by at least 9% of women. In an exploratory analysis, 12 variables were tested in logistic regression models for each comorbid condition, including demographic variables, environmental variables, PM-associated factors, and endorsement of depression and/or anxiety. More than half of the comorbid conditions studied were associated with women who self-reported having anxiety. Age, smoking, body mass index (BMI), and depression were also significant predictor variables for specific comorbid conditions. Conclusions: Age, smoking, and BMI were significantly associated with a subset of the comorbid conditions analyzed. Importantly, depression or anxiety were also significantly associated with many of the comorbid health conditions. This work highlights some of the modifiable factors associated with complex health profiles among women with an FMR1 PM.
登录
查看更多内容
影响因子：
2.6
作者：
Pirker W;Katzenschlager R
通讯作者：
Katzenschlager R
影响因子：
64.5
作者：
FU, YH;KUHL, DPA;CASKEY, CT
通讯作者：
CASKEY, CT
影响因子：
13.6
作者：
Movaghar, Arezoo;Page, David;Mailick, Marsha R.
通讯作者：
Mailick, Marsha R.
影响因子：
4.2
作者：
Lee, Shin-Seok;Kim, Seong-Ho;Kim, Seong-Kyu
通讯作者：
Kim, Seong-Kyu
影响因子：
2.7
作者：
Cedars, Marcelle I.
通讯作者：
Cedars, Marcelle I.