Stress-induced reactive oxygen species compartmentalization, perception and signalling.

Stress-induced reactive oxygen species compartmentalization, perception and signalling.
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DOI:
10.1038/s41477-021-00887-0
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发表时间:
2021-04
期刊:
影响因子:
18
通讯作者:
Coaker G
Coaker G
中科院分区:
生物学1区
文献类型:
--
作者:
Castro B;Citterico M;Kimura S;Stevens DM;Wrzaczek M;Coaker G

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活性氧(ROS)对生命至关重要,几乎参与了所有生物过程的调节。活性氧的产生对植物的发育、对非生物胁迫的反应和免疫反应至关重要。ROS也可以引起直接的氧化损伤,因此生物体必须平衡ROS的产生和猝灭。在这里,我们关注ROS生物学的最新发现,强调非生物和生物应激反应。最近的进展导致鉴定了细胞外ROS的第一个传感器之一,并强调了拟南芥在胁迫信号传导过程中ROS产生的波。产生ROS的酶,包括NADPH氧化酶,通过多种翻译后修饰表现出精确的调控。这些发现强调了通过蛋白质磷酸化和半胱氨酸氧化对NADPH氧化酶的N端和c端调控的重要性。在这里,我们讨论了在ROS区隔化、系统ROS波、ROS传感和ROS产生酶的翻译后修饰方面的进展,并确定了基础空白仍然存在的领域。
Reactive oxygen species (ROS) are essential for life and involved in the regulation of almost all biological processes. ROS production is critical for plant development, response to abiotic stresses, and immune responses. ROS can also cause direct oxidative damage and organisms must therefore balance ROS production and quenching. Here, we focus on recent discoveries in ROS biology emphasizing abiotic and biotic stress responses. Recent advancements have resulted in the identification of one of the first sensors for extracellular ROS and highlighted waves of ROS production during stress signaling in Arabidopsis. Enzymes that produce ROS, including NADPH oxidases, exhibit precise regulation through diverse posttranslational modifications. Discoveries highlight the importance of both N- and C-terminal regulation of NADPH oxidases through protein phosphorylation and cysteine oxidation. Here, we discuss advancements in ROS compartmentalization, systemic ROS waves, ROS sensing, and posttranslational modification of ROS producing enzymes as well as identify areas where foundational gaps remain.
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