Pvt1-encoded microRNAs in oncogenesis.
Pvt1-encoded microRNAs in oncogenesis.
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DOI：
10.1186/1742-4690-5-4
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发表时间：
2008-01-14
期刊：
影响因子：
3.3
通讯作者：
Wabl M
中科院分区：
文献类型：
--
作者：
Beck-Engeser GB;Lum AM;Huppi K;Caplen NJ;Wang BB;Wabl M
PVT1基因在Burkitt淋巴瘤和浆细胞瘤发生中的功能意义一直是个谜。在这些肿瘤中，PVT1是免疫球蛋白基因座相互易位的部位。尽管该基因座编码了许多可供选择的转录本，但没有发现任何蛋白质或调控RNA产物。最近对PVT1区域内编码的非编码microRNA的发现表明，该基因座具有调节作用。小鼠PVT1基因座编码多个microRNA。在逆转录病毒插入该基因位点诱导的小鼠T细胞淋巴瘤中，PVT1转录本及其至少一个microRNA产物MMU-miR-1204过表达。虽然在一个肿瘤中可以发现多达七个共同突变，但在2000多个肿瘤中，没有一个同时插入Myc和PVT1基因。从PVT1基因座的大量整合来看--比邻近的Myc基因座更多--PVT1及其编码的microRNAs在T淋巴肿瘤的发生中与Myc一样重要，而且可能在T细胞激活中也是如此。对淋巴瘤共突变的分析可能会将PVT1和Myc置于同一途径。
The functional significance of the Pvt1 locus in the oncogenesis of Burkitt's lymphoma and plasmacytomas has remained a puzzle. In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loci. Although the locus encodes a number of alternative transcripts, no protein or regulatory RNA products were found. The recent identification of non-coding microRNAs encoded within the PVT1 region has suggested a regulatory role for this locus. The mouse Pvt1 locus encodes several microRNAs. In mouse T cell lymphomas induced by retroviral insertions into the locus, the Pvt1 transcripts, and at least one of their microRNA products, mmu-miR-1204 are overexpressed. Whereas up to seven co-mutations can be found in a single tumor, in over 2,000 tumors none had insertions into both the Myc and Pvt1 loci. Judging from the large number of integrations into the Pvt1 locus – more than in the nearby Myc locus – Pvt1 and the microRNAs encoded by it are as important as Myc in T lymphomagenesis, and, presumably, in T cell activation. An analysis of the co-mutations in the lymphomas likely place Pvt1 and Myc into the same pathway.
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影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
影响因子：
64.8
作者：
HAYWARD, WS;NEEL, BG;ASTRIN, SM
通讯作者：
ASTRIN, SM
影响因子：
5.3
作者：
Hoemann, CD;Beaulieu, N;Jolicoeur, P
通讯作者：
Jolicoeur, P
影响因子：
64.8
作者：
NUSSE, R;VANOOYEN, A;VARMUS, H
通讯作者：
VARMUS, H
DOI：
10.1073/pnas.86.9.3257
发表时间：
1989-05-01
影响因子：
11.1
作者：
SHTIVELMAN, E;HENGLEIN, B;BISHOP, JM
通讯作者：
BISHOP, JM