Comparison of different metabolic syndrome definitions and risks of incident cardiovascular events in the elderly.
Comparison of different metabolic syndrome definitions and risks of incident cardiovascular events in the elderly.
复制标题
DOI：
10.1016/j.metabol.2011.07.002
复制
发表时间：
2012-03
影响因子：
9.8
通讯作者：
Cheang, Kai I.
中科院分区：
文献类型：
--
作者：
Vinluan, Celeste M.;Zreikat, Halo H.;Levy, James R.;Cheang, Kai I.
代谢综合征与心血管风险增加有关，其患病率随着年龄的增加而增加。代谢综合征有多种定义，但一些定义是否更能预测老年人未来的心血管事件尚不清楚。我们比较了来自心血管健康研究的65岁老年人在有和没有代谢综合征的情况下发生心血管事件的风险，这些代谢综合征由EGIR、NCEP/≥、AACE、IDF和修订的WHO标准定义(n=3390)。参与者没有糖尿病或心血管疾病的基线。除EGIR外，所有代谢综合征的定义均与心血管(冠脉或脑血管)事件风险增加显著相关。根据修订的世卫组织、NCEP/AHA、AACE和IDF标准定义的事件心血管事件风险的调整危险比(HR)从NCEP/AHA的1.153(p=0.045)到IDF的1.314(p<；0.001)不等，95%可信区间为1.003-1.503。调整后的心率为1.087(95%可信区间为0.908-1.301，p=0.362)。类似地，除EGIR定义外，代谢综合征的所有定义都与冠状动脉事件显著相关。只有修改后的WHO定义与脑血管事件风险增加相关(调整后的HR为1.301，95%CI为1.038-1.631，p=0.022)。虽然除EGIR外的所有代谢综合征定义都与总的心血管事件和冠状动脉事件相关，但只有修改后的WHO定义也与脑血管事件的风险相关。
The metabolic syndrome is associated with increased cardiovascular risk and its prevalence increases with age. Various definitions of the metabolic syndrome exist, but whether some definitions are more predictive of future cardiovascular events in the elderly is unclear. We compared the risk of incident cardiovascular events in elderly individuals ≥ 65 years from the Cardiovascular Health Study with and without the metabolic syndrome as defined by the EGIR, NCEP/AHA, AACE, IDF and modified WHO criteria (n=3390). Participants were without baseline diabetes or cardiovascular disease. Except for EGIR, all definitions of the metabolic syndrome were significantly associated with increased risk of incident cardiovascular (coronary or cerebrovascular) events. Adjusted hazard ratios (HRs) for risk of incident cardiovascular events as defined by the modified WHO, NCEP/AHA, AACE and IDF criteria ranged from 1.153 (p=0.045) for NCEP/AHA to 1.314 (p<0.001) for IDF, with 95% CI ranging from 1.003–1.503. Adjusted HR for EGIR was 1.087 (95% CI 0.908–1.301, p=0.362). Similarly, all definitions of the metabolic syndrome were significantly associated with incident coronary events except for the EGIR definition. Only the modified WHO definition was associated with increased risk for cerebrovascular events (adjusted HR 1.301, 95% CI 1.038–1.631, p=0.022). While all metabolic syndrome definitions except EGIR were associated with total cardiovascular events and coronary events, only the modified WHO definition was also associated with risk of cerebrovascular events.
登录
查看更多内容
影响因子：
37.8
作者：
Dekker, JM;Girman, C;Heine, RJ
通讯作者：
Heine, RJ
影响因子：
7.7
作者：
Alexander, CM;Landsman, PB;Haffner, SM
通讯作者：
Haffner, SM
影响因子：
16.2
作者：
Bonora, E;Saggiani, F;Muggeo, M
通讯作者：
Muggeo, M
影响因子：
120.7
作者：
Lakka, HM;Laaksonen, DE;Salonen, JT
通讯作者：
Salonen, JT
影响因子：
37.8
作者：
Malik, S;Wong, ND;Williams, GR
通讯作者：
Williams, GR