Opiate receptor inhibition improves the blunted baroreflex function in conscious dogs with right-sided congestive heart failure.
Opiate receptor inhibition improves the blunted baroreflex function in conscious dogs with right-sided congestive heart failure.
复制标题
阿片受体抑制可改善患有右侧充血性心力衰竭的清醒犬的压力反射功能减弱。
DOI：
10.1161/01.cir.80.4.1010
复制
发表时间：
1989
期刊：
影响因子：
37.8
通讯作者：
Liang,CS
中科院分区：
文献类型：
--
作者：
Sakamoto,S;Liang,CS
内源性阿片系统在充血性心力衰竭中被激活。由于已知内源性阿片类物质抑制压力反射功能，我们进行了研究以确定增加的内源性阿片类物质是否在引起心力衰竭中发生的压力反射功能降低中起作用。用三尖瓣撕脱和进行性肺动脉缩窄造成16只犬右心充血性心力衰竭。包括7只假手术犬进行比较。在清醒的狗中测量压力反射功能，无论是用生理盐水或阿片受体拮抗剂通过推注给药苯肾上腺素预处理后。以收缩压与心动周期（R-R）间期的回归线斜率作为压力反射敏感性的指标。心力衰竭犬的血浆β-内啡肽水平（15.3 +/- 2.5 pmol/l）高于假手术犬（4.2 +/- 0.4 pmol/l，p <0.001）。与假手术犬（10.86 +/- 1.20 msec/mm Hg，p <0.001）相比，盐水预处理后心力衰竭犬的压力反射敏感性也降低（3.84 +/- 0.19 msec/mm Hg）。盐酸纳洛酮给药使心力衰竭犬的压力反射敏感性增加至5.16 +/- 0.26 msec/mm Hg（p <0.01），但对假手术犬无显著影响（11.36 +/- 1.42 msec/mm Hg）。为了进一步研究纳洛酮作用的作用部位，我们测量了心力衰竭犬在用选择性μ受体拮抗剂纳洛嗪、选择性δ受体拮抗剂ICI 154，129或不穿透血脑屏障的纳洛酮四元类似物纳洛酮甲溴化物预处理后的压力反射敏感性。（250字处删节）
The endogenous opiate system is activated in congestive heart failure. because endogenous opioids are known to depress the baroreflex function, we conducted studies to determine whether the increased endogenous opioids play a role in causing the reduced baroreflex function that occurs in heart failure. Right-sided congestive heart failure was produced in 16 dogs by tricuspid avulsion and progressive pulmonary artery constriction. Seven sham-operated dogs were included for comparison. Baroreflex function was measured in the conscious dogs after pretreatment with either normal saline or an opiate-receptor antagonist by bolus administration of phenylephrine. The slope of the regression line relating systolic blood pressure to cardiac cycle (R-R) interval was taken as an index of baroreflex sensitivity. Plasma beta-endorphin was elevated in the dogs with heart failure (15.3 +/- 2.5 pmol/l) compared with the sham-operated dogs (4.2 +/- 0.4 pmol/l, p less than 0.001). The dogs with heart failure also exhibited a reduced baroreflex sensitivity (3.84 +/- 0.19 msec/mm Hg) after saline pretreatment when compared with the sham-operated dogs (10.86 +/- 1.20 msec/mm Hg, p less than 0.001). Administration of naloxone hydrochloride increased the baroreflex sensitivity of dogs with heart failure to 5.16 +/- 0.26 msec/mm Hg (p less than 0.01) but produced no significant effects in sham-operated dogs (11.36 +/- 1.42 msec/mm Hg). To further study the site of action for the effect of naloxone, we measured baroreflex sensitivity in the dogs with heart failure after pretreatment with naloxonazine, a selective mu-receptor antagonist, with ICI 154,129, a selective delta-receptor antagonist, or with naloxone methobromide, a quaternary analogue of naloxone that does not penetrate the blood-brain barrier.(ABSTRACT TRUNCATED AT 250 WORDS)
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影响因子：
5
作者：
RUSSELL, J;BASS, P;MERZ, H
通讯作者：
MERZ, H
阿片类拮抗剂纳洛酮可改善电休克 (ECS) 对呼吸、血压和心率的影响
影响因子：
2.9
作者：
G. Belenky;J. Holaday
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影响因子：
10.8
作者：
C. Higgins;R. Pavelec;S. Vatner
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S. Vatner
患有心力衰竭的意识清醒的狗的压力感受器反射的改变。
影响因子：
15.9
作者：
C. Higgins;S. Vatner;D. Eckberg;E. Braunwald
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E. Braunwald
加压素 V1 受体抑制对慢性右侧充血性心力衰竭的短期血流动力学影响。
影响因子：
37.8
作者：
Stone,CK;Liang,CS;Imai,N;Sakamoto,S;Sladek,CD;HoodJr,WB
通讯作者：
HoodJr,WB