Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation: Ex-vivo.
Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation: Ex-vivo.
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DOI：
10.1016/j.pacs.2023.100538
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发表时间：
2023-08
期刊：
影响因子：
7.9
通讯作者：
Avanaki, Kamran
中科院分区：
文献类型：
--
作者：
Manwar, Rayyan;Kratkiewicz, Karl;Mahmoodkalayeh, Sadreddin;Hariri, Ali;Papadelis, Christos;Hansen, Anne;Pillers, De-Ann M.;Gelovani, Juri;Avanaki, Kamran
我们已经开发并优化了一种成像系统，以研究和改善脑出血的检测并量化氧合。由于该系统预期用于通过颅骨开口对新生儿进行脑成像，即，我们称之为经<$门光声成像系统。该系统在光学和声学设计、热安全性和机械稳定性方面进行了优化。使用体外和离体实验评价TFPAI检测出血位置及其大小的定量下限。TFPAI在测量组织氧合和检测由于脑血屏障破坏的血管源性水肿的能力得到证明。从我们的实验评估中获得的结果强烈表明TFPAI作为新生儿重症监护室中的便携式成像方式的潜在效用。在体内证实这些发现可以促进这种有前途的技术向临床的转化。
We have developed and optimized an imaging system to study and improve the detection of brain hemorrhage and to quantify oxygenation. Since this system is intended to be used for brain imaging in neonates through the skull opening, i.e., fontanelle, we called it, Transfontanelle Photoacoustic Imaging (TFPAI) system. The system is optimized in terms of optical and acoustic designs, thermal safety, and mechanical stability. The lower limit of quantification of TFPAI to detect the location of hemorrhage and its size is evaluated using in-vitro and ex-vivo experiments. The capability of TFPAI in measuring the tissue oxygenation and detection of vasogenic edema due to brain blood barrier disruption are demonstrated. The results obtained from our experimental evaluations strongly suggest the potential utility of TFPAI, as a portable imaging modality in the neonatal intensive care unit. Confirmation of these findings in-vivo could facilitate the translation of this promising technology to the clinic.
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