Optimal configuration of a low-dose breast-specific gamma camera based on semiconductor CdZnTe pixelated detectors
Optimal configuration of a low-dose breast-specific gamma camera based on semiconductor CdZnTe pixelated detectors
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基于半导体 CdZnTe 像素化探测器的低剂量乳腺专用伽马相机的优化配置
DOI：
10.1088/1742-6596/841/1/012012
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Genocchi B
中科院分区：
文献类型：
--
作者：
Genocchi B
乳腺癌是女性中最常见的肿瘤之一。在90年代，筛查项目的引入使得癌症在可触及阶段之前就被发现，将其死亡率降低了50%。约50%的30至50岁的女性表现为致密的乳腺实质。在50至80岁的女性中，这一比例降至30%。在这些女性中，乳房x光检查的灵敏度约为30%，小肿瘤被致密的实质覆盖，在乳房x光检查中未被发现。有趣的是，基于半导体CdZnTe探测器的乳腺特异性伽马照相机对早期诊断显示出极大的兴趣。事实上，由于CdZnTe的高能量、空间分辨率和高灵敏度，已经证明分子乳腺成像的灵敏度约为90%，与乳腺实质无关。本工作的目的是确定基于CdZnTe像素化探测器的140 keV低剂量双头乳房特定伽马相机中探测器像素尺寸、孔形状和准直器材料的最佳组合，以实现高计数率和最佳图像空间分辨率。利用蒙特卡罗代码GATE对系统进行建模，研究了最优组合。考虑了0.85 mm至1.6 mm的6种不同像素尺寸、六角形和方形两种孔形以及铅和钨两种不同准直器材料。实验结果表明，采用方孔和大像素（> 1.3 mm）时，相机具有更高的计数率和更好的信噪比。在这些配置下，空间分辨率比使用小像素尺寸（< 1.3 mm）时差，但在所有情况下都保持在3.6 mm以下。
Breast cancer is one of the most frequent tumours in women. During the'90s, the introduction of screening programmes allowed the detection of cancer before the palpable stage, reducing its mortality up to 50%. About 50% of the women aged between 30 and 50 years present dense breast parenchyma. This percentage decreases to 30% for women between 50 to 80 years. In these women, mammography has a sensitivity of around 30%, and small tumours are covered by the dense parenchyma and missed in the mammogram. Interestingly, breast-specific gamma-cameras based on semiconductor CdZnTe detectors have shown to be of great interest to early diagnosis. Infact, due to the high energy, spatial resolution, and high sensitivity of CdZnTe, molecular breast imaging has been shown to have a sensitivity of about 90% independently of the breast parenchyma. The aim of this work is to determine the optimal combination of the detector pixel size, hole shape, and collimator material in a low dose dual head breast specific gamma camera based on a CdZnTe pixelated detector at 140 keV, in order to achieve high count rate, and the best possible image spatial resolution. The optimal combination has been studied by modeling the system using the Monte Carlo code GATE. Six different pixel sizes from 0.85 mm to 1.6 mm, two hole shapes, hexagonal and square, and two different collimator materials, lead and tungsten were considered. It was demonstrated that the camera achieved higher count rates, and better signal-to-noise ratio when equipped with square hole, and large pixels (> 1.3 mm). In these configurations, the spatial resolution was worse than using small pixel sizes (< 1.3 mm), but remained under 3.6 mm in all cases.
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用于 X 射线和 γ 射线成像应用的像素化 CdZnTe 探测器的计算建模
DOI：
--
发表时间：
2012
期刊：
影响因子：
--
作者：
M. Myronakis;M. Zvelebil;D. Darambara
通讯作者：
D. Darambara
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DOI：
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发表时间：
2003
期刊：
影响因子：
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作者：
C. Levin
通讯作者：
C. Levin
影响因子：
3.5
作者：
Ma, Andy K. W.;Gunn, Spencer;Darambara, Dimitra G.
通讯作者：
Darambara, Dimitra G.
影响因子：
3.8
作者：
Weinmann,AmandaL;Hruska,CarrieB;O'Connor,MichaelK
通讯作者：
O'Connor,MichaelK