Interrogating the relationship between the microstructure of amphiphilic poly(ethylene glycol-b-caprolactone) copolymers and their colloidal assemblies using non-interfering techniques.
Interrogating the relationship between the microstructure of amphiphilic poly(ethylene glycol-b-caprolactone) copolymers and their colloidal assemblies using non-interfering techniques.
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DOI：
10.1016/j.jcis.2021.08.084
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发表时间：
2022-01-15
影响因子：
9.9
通讯作者：
Blencowe A
中科院分区：
文献类型：
--
作者：
Faisal KS;Clulow AJ;Krasowska M;Gillam T;Miklavcic SJ;Williamson NH;Blencowe A
了解控制聚集胶体形成和结构的两亲共聚物的微观结构参数（例如，胶束）对于合理设计应用于纳米医学、个人护理和食品配方的分级结构体系是必不可少的。虽然许多分析技术已经被用来研究这样的系统，在这项调查中，我们采用了一个综合的方法，使用非干扰技术-扩散核磁共振（NMR）光谱，动态光散射（DLS）和同步加速器小角X射线散射（SAXS）-来探测聚（乙二醇-b-己内酯）（PEG-b-PCL）共聚物的微观结构之间的关系[例如，嵌段分子量（MW）和PCL的质量分数（fPCL）]及其聚集体的结构。使用具有可变PEG和PCL嵌段长度（数均分子量（Mn）分别在2-10和0.5-15 kDa之间）和窄分散度（Mn < 1.12）的大家族的明确定义的嵌段共聚物来确定自组装行为的系统趋势。对于所有的共聚物，当疏水性fPCL在恒定的PEG嵌段Mn下增加时，观察到聚集体结构的明显转变，尽管这种转变的性质也取决于PEG嵌段Mn。观察到具有低Mn PEG嵌段（2kDa）的共聚物从单聚体和松散缔合的单聚体过渡到亚稳聚集体，最后，随着fPCL的增加，过渡到限定的圆柱形胶束。相比之下，具有5至10 kDa的PEG嵌段Mn的共聚物随着fPCL的增加从异相亚稳聚集体转变为圆柱形胶束，最后转变为轮廓分明的椭圆形胶束（纵横比减小）。在所有情况下，扩散NMR光谱，DLS和同步加速器SAXS的结果提供了互补的信息和理由的相图共聚物微观结构的聚集行为和结构。重要的是，通常描绘的球形胶束的情况下，有影响的应用程序，其中的性质可能是由形状，如细胞摄取的纳米药物制剂。
Understanding the microstructural parameters of amphiphilic copolymers that control the formation and structure of aggregated colloids (e.g., micelles) is essential for the rational design of hierarchically structured systems for applications in nanomedicine, personal care and food formulations. Although many analytical techniques have been employed to study such systems, in this investigation we adopted an integrated approach using non-interfering techniques – diffusion nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS) and synchrotron small-angle X-ray scattering (SAXS) – to probe the relationship between the microstructure of poly(ethylene glycol-b-caprolactone) (PEG-b-PCL) copolymers [e.g., block molecular weight (MW) and the mass fraction of PCL (fPCL)] and the structure of their aggregates. Systematic trends in the self-assembly behaviour were determined using a large family of well-defined block copolymers with variable PEG and PCL block lengths (number-average molecular weights (Mn) between 2–10 and 0.5–15 kDa, respectively) and narrow dispersity (Ð < 1.12). For all of the copolymers, a clear transition in the aggregate structure was observed when the hydrophobic fPCL was increased at a constant PEG block Mn, although the nature of this transition is also dependent on the PEG block Mn. Copolymers with low Mn PEG blocks (2 kDa) were observed to transition from unimers and loosely associated unimers to metastable aggregates and finally, to defined cylindrical micelles as the fPCL was increased. In comparison, copolymers with PEG block Mn of between 5 and 10 kDa transitioned from heterogenous metastable aggregates to cylindrical micelles and finally, well-defined ellipsoidal micelles (of decreasing aspect ratios) as the fPCL was increased. In all cases, the diffusion NMR spectroscopy, DLS and synchrotron SAXS results provided complementary information and the grounds for a phase diagram relating copolymer microstructure to aggregation behaviour and structure. Importantly, the absence of commonly depicted spherical micelles has implications for applications where properties may be governed by shape, such as, cellular uptake of nanomedicine formulations.
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NK012的II期研究是一种不可切除的，转移或复发性的结直肠癌患者的SN-38的聚合物胶束制剂。
影响因子：
3
作者：
Hamaguchi T;Tsuji A;Yamaguchi K;Takeda K;Uetake H;Esaki T;Amagai K;Sakai D;Baba H;Kimura M;Matsumura Y;Tsukamoto T
通讯作者：
Tsukamoto T
影响因子：
15.6
作者：
BLANDAMER, MJ;CULLIS, PM;SUBHA, MCS
通讯作者：
SUBHA, MCS
DOI：
10.3390/ma11050688
发表时间：
2018-04-27
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Hussein YHA;Youssry M
通讯作者：
Youssry M
DOI：
10.1039/f29767201525
发表时间：
1976-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS II
影响因子：
--
作者：
ISRAELACHVILI, JN;MITCHELL, DJ;NINHAM, BW
通讯作者：
NINHAM, BW
影响因子：
10.8
作者：
Gaucher, G;Dufresne, MH;Leroux, JC
通讯作者：
Leroux, JC