Magnetic resonance diffusion-weighted imaging: reproducibility of regional apparent diffusion coefficients for the normal fetal brain.
Magnetic resonance diffusion-weighted imaging: reproducibility of regional apparent diffusion coefficients for the normal fetal brain.
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DOI：
10.1002/uog.11219
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发表时间：
2013-02
影响因子：
7.1
通讯作者：
Romero, R.
中科院分区：
文献类型：
--
作者：
Boyer, A. C.;Goncalves, L. F.;Lee, W.;Shetty, A.;Holman, A.;Yeo, L.;Romero, R.
探讨正常胎儿中、晚期脑局部表观弥散系数（ADC）测量的重复性。对50例妊娠19-37周的正常单胎胎儿进行了研究，未使用镇静剂。使用1.5特斯拉MR扫描仪和6通道体阵列线圈获得胎儿大脑的单次激发扩散DWI。沿沿着3个正交方向使用0和1000 b值创建ADC图。两名检查者独立测量小脑半球（CH）、脑桥、丘脑、基底节（BG）、半卵圆中心（CSO）、额叶（FWM）、顶叶（PWM）、颞叶（TWM）和枕叶白色物质（OWM）的ADC值。ADC值和月经年龄之间的相关性通过线性回归进行评估。使用Bland-Altman图确定ADC测量的偏倚和一致性。随着月经年龄的增加，ADC值保持不变（BG，FWM，PWM，TWM，CSO）或降低（CH，脑桥，丘脑）。ADC测量的平均观察者内偏倚与零无显著差异。CH（1.26 ± 0.20 vs. 1.20 ± 0.18，p = 0.006）、PWM（1.37 ± 0.29 vs. 1.33 ± 0.26，p = 0.02）和CSO（1.36 ± 0.29 vs. 1.33 ± 0.28，p < 0.0001）的观察者间偏倚差异较小。测量一致性可接受。正常未镇静胎儿在第二和第三孕期的ADC测量是可重复的，除了检查者之间PWM，CH和CSO的小差异。
To evaluate the reproducibility of regional apparent diffusion coefficient (ADC) measurements of the normal fetal brain in the second and third trimesters. Fifty normal singleton fetuses between 19–37 weeks of gestation were studied without sedation from healthy pregnant women. Single-shot diffusion DWI of the fetal brain was obtained using a 1.5-Tesla MR scanner and a 6-channel body array coil. ADC maps were created using 0 and 1000 b-values along 3 orthogonal directions. Two examiners independently measured ADC values in the cerebellar hemispheres (CH), pons, thalamus, basal ganglia (BG), centrum semiovale (CSO), frontal (FWM), parietal (PWM), temporal (TWM), and occipital white matter (OWM). Correlation between ADC values and menstrual age was assessed by linear regression. The bias and agreement of ADC measurements were determined using Bland-Altman plots. ADC values either remained constant (BG, FWM, PWM, TWM, CSO) or decreased (CH, pons, thalamus) with advancing menstrual age. Mean intra-observer bias for ADC measurements was not significantly different from zero. Small differences in inter-observer bias were detected for CH (1.26 ± 0.20 vs. 1.20 ± 0.18, p = 0.006), PWM (1.37 ± 0.29 vs. 1.33 ± 0.26, p = 0.02), and CSO (1.36 ± 0.29 vs. 1.33 ± 0.28, p < 0.0001). Measurement agreement was acceptable. ADC measurements in normal un-sedated fetuses in the second and third trimesters are reproducible except for small differences for PWM, CH, and CSO between examiners.
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影响因子：
8.3
作者：
Kucinski, T;V채terlein, O;Zeumer, H
通讯作者：
Zeumer, H
影响因子：
3.7
作者：
Kostovic, I;Judas, M;Hrabac, P
通讯作者：
Hrabac, P
影响因子：
3.5
作者：
Guilmiot, F.;Garel, C.;Delezoide, A. -L.
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影响因子：
8.9
作者：
Manganaro, L.;Perrone, A.;Marini, M.
通讯作者：
Marini, M.
DOI：
10.1016/s1064-9689(03)00065-5
发表时间：
2003-08-01
影响因子：
1.6
作者：
Barboriak, Daniel P
通讯作者：
Barboriak, Daniel P