A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research.
A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research.
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DOI：
10.1002/alz.12382
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
HABLE Study Team
中科院分区：
文献类型：
--
作者：
O'Bryant SE;Zhang F;Petersen M;Hall JR;Johnson LA;Yaffe K;Mason D;Braskie M;Barber RA;Rissman RA;Mapstone M;Mielke MM;Toga AW;HABLE Study Team
Representation of Mexican Americans in Alzheimer's disease (AD) clinical research has been extremely poor. Data were examined from the ongoing community‐based, multi‐ethnic Health & Aging Brain among Latino Elders (HABLE) study. Participants underwent functional exams, clinical labs, neuropsychological testing, and 3T magnetic resonance imaging of the brain. Fasting proteomic markers were examined for predicting mild cognitive impairment (MCI) and AD using support vector machine models. Data were examined from n = 1649 participants (Mexican American n = 866; non‐Hispanic White n = 783). Proteomic profiles were highly accurate in detecting MCI (area under the curve [AUC] = 0.91) and dementia (AUC = 0.95). The proteomic profiles varied significantly between ethnic groups and disease state. Negative predictive value was excellent for ruling out MCI and dementia across ethnic groups. A blood‐based screening tool can serve as a method for increasing access to state‐of‐the‐art AD clinical research by bridging between community‐based and clinic‐based settings.
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影响因子：
29
作者：
Janelidze S;Berron D;Smith R;Strandberg O;Proctor NK;Dage JL;Stomrud E;Palmqvist S;Mattsson-Carlgren N;Hansson O
通讯作者：
Hansson O
影响因子：
7
作者：
Faison, Warachal E.;Schultz, Susan K.;Mintzer, Jacobo E.
通讯作者：
Mintzer, Jacobo E.
影响因子：
--
作者：
O'Bryant, Sid E.;Xiao, Guanghua;Barber, Robert;Reisch, Joan;Doody, Rachelle;Fairchild, Thomas;Adams, Perrie;Waring, Steven;Diaz-Arrastia, Ramon
通讯作者：
Diaz-Arrastia, Ramon
DOI：
10.1016/j.dadm.2016.06.004
发表时间：
2016
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
O'Bryant SE;Edwards M;Johnson L;Hall J;Villarreal AE;Britton GB;Quiceno M;Cullum CM;Graff-Radford NR
通讯作者：
Graff-Radford NR
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH