Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback.
Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback.
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自我加工神经反馈后抑郁青少年的神经活动与症状变化相关
DOI：
10.3390/brainsci12091128
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发表时间：
2022-08-25
期刊：
影响因子：
3.3
通讯作者：
Quevedo, Karina
中科院分区：
文献类型：
--
作者：
Ahrweiler, Natasha;Santana-Gonzalez, Carmen;Zhang, Na;Quandt, Grace;Ashtiani, Nikki;Liu, Guanmin;Engstrom, Maggie;Schultz, Erika;Liengswangwong, Ryan;Teoh, Jia Yuan;Kozachok, Katia;Quevedo, Karina
关键词：
青少年抑郁症是普遍的，衰弱的，并与慢性终身心理健康障碍。了解抑郁症的神经生物学对于开发新的治疗方法至关重要。我们测试了针对情绪调节和自我处理电路的神经反馈协议，并检查了与症状严重程度降低相关的大脑活动，通过自我报告问卷进行测量，神经反馈后4小时。抑郁（n = 34）和健康（n = 19）的青少年参与（i）一个简短的神经反馈任务，包括同时查看自己的快乐的脸，回忆积极的自传体记忆，并增加杏仁核-海马活动;（ii）自我与他人的面部识别任务与快乐，中性，和悲伤的面部表情之前和之后的神经反馈。在抑郁的青年中，神经反馈后抑郁的减少与神经反馈期间自我参照和视觉区域活动的增加有关，特别是楔叶，楔前叶和顶叶的活动增加。在自我认知任务中，抑郁症的减少也与情绪调节和跨模态区域的激活增加有关。这些区域包括小脑、颞中回、上级颞回和缘上回。然而，反刍减少与神经反馈过程中楔前叶、角回和颞回活动减少有关。这些结果初步表明，神经反馈可能会导致短期的神经生物学变化的自我参考和情绪调节网络与抑郁症的青少年症状严重程度降低。
Adolescent depression is prevalent, debilitating, and associated with chronic lifetime mental health disorders. Understanding the neurobiology of depression is critical to developing novel treatments. We tested a neurofeedback protocol targeting emotional regulation and self-processing circuitry and examined brain activity associated with reduced symptom severity, as measured through self-report questionnaires, four hours after neurofeedback. Depressed (n = 34) and healthy (n = 19) adolescents participated in (i) a brief neurofeedback task that involves simultaneously viewing their own happy face, recalling a positive autobiographical memory, and increasing amygdala-hippocampal activity; (ii) a self- vs. other- face recognition task with happy, neutral, and sad facial expressions before and after the neurofeedback. In depressed youth, reduced depression after neurofeedback was associated with increased self-referential and visual areas’ activity during neurofeedback, specifically, increased activity in the cuneus, precuneus and parietal lobe. Reduced depression was also associated with increased activation of emotional regulation and cross-modal areas during a self-recognition task. These areas included the cerebellum, middle temporal gyrus, superior temporal gyrus, and supramarginal gyrus. However, decreased rumination was linked to decreased precuneus, angular and temporal gyri activity during neurofeedback. These results tentatively suggest that neurofeedback may induce short-term neurobiological changes in the self-referential and emotional regulation networks associated with reduced symptom severity among depressed adolescents.
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