Ultrastructural demonstration of the absorption and transportation of minute chylomicrons by subepithelial blood capillaries in rat jejunal villi.
Ultrastructural demonstration of the absorption and transportation of minute chylomicrons by subepithelial blood capillaries in rat jejunal villi.
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DOI：
10.1292/jvms.13-0310
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发表时间：
2013-12-30
期刊：
影响因子：
--
通讯作者：
Kitagawa H
中科院分区：
文献类型：
--
作者：
Takahara E;Mantani Y;Udayanga KG;Qi WM;Tanida T;Takeuchi T;Yokoyama T;Hoshi N;Kitagawa H
来自绒毛柱状上皮细胞的乳糜微粒通常只通过中央淋巴管（CLV）运输，而来自肠腔的抗原颗粒也可以通过大鼠肠绒毛的上皮下毛细血管（sbc）运输。透射电镜下对大鼠空肠内sbc吸收乳糜微粒的可能性进行了组织计量学研究。乳糜微粒在绒毛小静脉中比在小动脉中更为丰富。乳糜微粒最常见的大小（MFS）为75 - 90 nm，在sbc附近的区域，而在sbc上方的上皮细胞间隙或sbc之间的中间区域，乳糜微粒的直径为45 - 60 nm。乳糜微粒在sbc之间的中间区域和这些区域上方的上皮细胞间隙内的MFS为45 ~ 60 nm。CLV乳糜微粒的MFS介于邻近sbc区域和sbc之间的中间区域之间。乳糜微粒存在于sbc内皮细胞质的小泡中。固有层未见大于600 nm的乳糜微粒。这些结果提示，在生理条件下，部分小于75 nm的乳糜微粒（可能是肠道极低密度脂蛋白（VLDL））除CLV外，还可通过肝门静脉血直接转运到肝脏，而大于600 nm的上皮脂肪滴并未排入大鼠空肠固有层。
Chylomicrons from villous columnar epithelial cells are generally known to be transported only by central lymph vessels (CLV), whereas antigenic particulates derived from the intestinal lumen can also be transported by subepithelial blood capillaries (sBCs) in rat intestinal villi. The possibility of chylomicron absorption by sBCs was histoplanimetrically studied in the rat jejunum under a transmission electron microscope. The chylomicrons more abundantly presented in villous venules than in arterioles. The most frequent size (MFS) of chylomicrons was 75 to 90 nm in diameter in the areas near sBCs, while it was 45 to 60 nm in the epithelial intercellular spaces just above sBCs or the intermediate areas between sBCs. The MFS of chylomicrons was 45 to 60 nm in the intermediate areas between sBCs and in the epithelial intercellular spaces just above these areas. The MFS of chylomicrons in CLV was intermediate between that in the area adjacent to sBCs and that in the intermediate areas between sBCs. Chylomicrons were found in small vesicles in the endothelial cytoplasms of sBCs. No chylomicrons larger than 600 nm were observed in the lamina propria. These findings suggest that some of the chylomicrons smaller than 75 nm, which are probable intestinal very low-density lipoproteins (VLDL), are directly transported to the liver by hepatic portal blood in addition to CLV and that epithelial fat droplets larger than 600 nm are not discharged into lamina propria in rat jejunum under physiological conditions.
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影响因子：
3.7
作者：
FRIEDMAN, HI;CARDELL, RR
通讯作者：
CARDELL, RR
影响因子：
4.5
作者：
SIMON, L;SHINE, G;DAYAN, AD
通讯作者：
DAYAN, AD
影响因子：
3.8
作者：
Hillyer, JF;Albrecht, RM
通讯作者：
Albrecht, RM
DOI：
10.1073/pnas.86.23.9318
发表时间：
1989-12-01
影响因子：
11.1
作者：
LUND, H;TAKAHASHI, K;HAVEL, RJ
通讯作者：
HAVEL, RJ
影响因子：
15.9
作者：
GIANTURCO, SH;LIN, AHY;BRADLEY, WA
通讯作者：
BRADLEY, WA