Sharing an environment with sick conspecifics alters odors of healthy animals.
Sharing an environment with sick conspecifics alters odors of healthy animals.
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DOI：
10.1038/s41598-018-32619-4
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发表时间：
2018-09-24
影响因子：
4.6
通讯作者：
Kimball BA
中科院分区：
文献类型：
--
作者：
Gervasi SS;Opiekun M;Martin T;Beauchamp GK;Kimball BA
体臭随健康状况的变化而变化，患病动物的体臭可诱发健康同种动物的回避行为。接触疾病气味也可能改变健康同种动物的生理，并改变它们产生的气味。我们假设，暴露在生病（但非传染性）动物的气味中会改变健康笼子里动物的气味。为了诱发疾病，我们给小鼠注射了一种细菌内毒素——脂多糖。我们使用行为气味辨别测试和分析化学技术，然后使用预测分类建模来询问两种健康小鼠：与健康同种和与患病同种居住的小鼠产生的挥发性气味的差异。在y型迷宫行为试验中训练的小鼠能够区分健康小鼠和患病小鼠的气味，也能够区分与患病同种同种住在一起的健康小鼠和与健康同种住在一起的健康小鼠的气味。化学分析与统计模型相结合揭示了一个相似的现象。根据判别模型预测，与患病伴侣住在一起的健康小鼠的尿液挥发物更有可能被归类为患病小鼠，而不是健康小鼠。与疾病相关的气味可能对健康同种动物的神经内分泌或免疫反应产生级联效应，并可能影响个体行为、社会动态和病原体传播。
Body odors change with health status and the odors of sick animals can induce avoidance behaviors in healthy conspecifics. Exposure to sickness odors might also alter the physiology of healthy conspecifics and modify the odors they produce. We hypothesized that exposure to odors of sick (but non-infectious) animals would alter the odors of healthy cagemates. To induce sickness, we injected mice with a bacterial endotoxin, lipopolysaccharide. We used behavioral odor discrimination assays and analytical chemistry techniques followed by predictive classification modeling to ask about differences in volatile odorants produced by two types of healthy mice: those cohoused with healthy conspecifics and those cohoused with sick conspecifics. Mice trained in Y-maze behavioral assays to discriminate between the odors of healthy versus sick mice also discriminated between the odors of healthy mice cohoused with sick conspecifics and odors of healthy mice cohoused with healthy conspecifics. Chemical analyses paired with statistical modeling revealed a parallel phenomenon. Urine volatiles of healthy mice cohoused with sick partners were more likely to be classified as those of sick rather than healthy mice based on discriminant model predictions. Sickness-related odors could have cascading effects on neuroendocrine or immune responses of healthy conspecifics, and could affect individual behaviors, social dynamics, and pathogen spread.
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影响因子：
3.8
作者：
Fox, Julie;Castro, Hannah;Fidler, Sarah
通讯作者：
Fidler, Sarah
影响因子：
8.2
作者：
Apfelbach, R;Blanchard, CD;McGregor, IS
通讯作者：
McGregor, IS
DOI：
10.1073/pnas.1214249110
发表时间：
2013-03-19
影响因子：
11.1
作者：
Brechuehl, Julien;Moine, Fabian;Broillet, Marie-Christine
通讯作者：
Broillet, Marie-Christine
影响因子：
2.5
作者：
Beltran-Bech, Sophie;Richard, Freddie-Jeanne
通讯作者：
Richard, Freddie-Jeanne
影响因子：
2.4
作者：
COTE, IM;POULIN, R
通讯作者：
POULIN, R