Heart rate mean and variability as a biomarker for phenotypic variation in preschoolers with autism spectrum disorder.
Heart rate mean and variability as a biomarker for phenotypic variation in preschoolers with autism spectrum disorder.
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DOI：
10.1002/aur.1982
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Webb SJ
中科院分区：
文献类型：
--
作者：
Bazelmans T;Jones EJH;Ghods S;Corrigan S;Toth K;Charman T;Webb SJ
人们对自闭症谱系障碍(ASD)自主觉醒的兴趣与日俱增；然而，这些测量方法在自闭症谱系障碍(ASD)中的可靠性尚不清楚，以前报道的与社会和认知能力之间的联系也不一致。这项研究评估了患有自闭症或典型发育障碍(TD)的学龄前儿童在被动观看自然视频时的心率(HR)和心率变异性(HRV)。评估测量信度、群体差异以及与社会和认知能力的关系。71名ASD和66名TD儿童(2-4岁)提供了两次会议的心脏数据。在三周的时间里，两组的HR和HRV的重测类内相关性都是中等到良好的。两组在心率或心率变异性的平均水平上没有差异。在ASD组中，会话内视频片段之间的HR的个体内变异性较高，但该指标的类内相关性较低。在TD儿童中，高HR与更好的语言技能有关，但在考虑了年龄和非语言能力后并不是这样。在控制了年龄和非语言能力后，ASD儿童的HRV越高，语言的表达和接受性越好。在12个月的随访中，HR/HRV与社交或执行功能技能无关，也没有解释能力的任何额外差异。综上所述，语言能力的变化与TD组的HR和ASD组的HRV有关。虽然这些结果是初步的，但这些结果对自主控制作为ASD个体差异的生物标志物的考虑是有希望的，并可能帮助我们理解有助于沟通技能的机制。心脏活动，如心率和心率变异性，与广泛的心理功能有关。这项研究表明，患有自闭症谱系障碍(ASD)的幼儿的心率与心率变异性和语言技能之间存在关联。这些结果可能有助于我们理解自闭症儿童在发展能力上的个体差异。
Interest in autonomic arousal in Autism Spectrum Disorder (ASD) is increasing; however, reliability of these measures in ASD is unknown and previously reported associations with social and cognitive abilities are inconsistent. This study assesses heart rate (HR) and heart rate variability (HRV) in preschoolers with ASD or typical development (TD) while they passively watched naturalistic videos. Measurement reliability, group differences, and the relationship with social and cognitive abilities were evaluated. 71 ASD and 66 TD children (2–4 years) provided cardiac data from two sessions. Test-retest intra-class correlations of HR and HRV over a three-week period were moderate to good in both groups. Groups did not differ in mean level of HR or HRV. Intra-individual variability of HR between video segments within a session was higher in the ASD group, but intra-class correlations of this metric were low. Higher HR related to better language skills in TD children, but not after accounting for age and non-verbal ability. Higher HRV related to better expressive and receptive language in ASD children after controlling for age and non-verbal ability. HR/HRV were not related to social or executive functioning skills and did not explain any additional variance in abilities at a 12-month follow-up visit. In summary, variation in language abilities is associated with HR in the TD group and HRV in the ASD group. Whilst preliminary, these results are promising for consideration of autonomic control as a biomarker for individual differences in ASD and may help us understand the mechanisms that contribute to communication skills. Cardiac activity, such as heart rate and heart rate variability, is linked to a wide range of psychological functions. This study shows that there is an association between heart rate and heart rate variability and language skills in young children with Autism Spectrum Disorder (ASD). These results may help us understand what underlies individual differences in developmental abilities in young children with ASD.
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影响因子：
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作者：
DoussardRoosevelt, JA;Porges, SW;Scanlon, KB
通讯作者：
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DOI：
10.1352/1944.7558-118.6.475
发表时间：
2013-11-01
影响因子：
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作者：
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作者：
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