Are corticothalamic 'up' states fragments of wakefulness?
Are corticothalamic 'up' states fragments of wakefulness?
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DOI：
10.1016/j.tins.2007.04.006
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发表时间：
2007-07
影响因子：
15.9
通讯作者：
Crunelli, Vincenzo
中科院分区：
文献类型：
--
作者：
Destexhe, Alain;Hughes, Stuart W.;Rudolph, Michelle;Crunelli, Vincenzo
缓慢（<1 Hz）振荡，沿着其在单个神经元中交替的向上和向下状态，是慢波睡眠期间EEG的定义特征。虽然这种振荡在哺乳动物物种中保存得很好，但其生理作用仍不清楚。来自皮层和丘脑的电生理学和计算证据现在表明，缓慢振荡的UP状态和觉醒的“激活”状态是非常相似的动态实体。这是一致的行为实验表明，缓慢振荡UP状态提供了一个背景下的重放和可能的巩固以前的经验。在这种情况下，T-型Ca2+通道依赖的动作电位爆发，启动每个UP状态在丘脑皮质神经元，可能会作为触发器的突触和细胞可塑性在皮质丘脑网络。
The slow (<1 Hz) oscillation, along with its alternating UP and DOWN states in individual neurons, is a defining feature of the EEG during slow-wave sleep. Although this oscillation is well preserved across mammalian species, its physiological role remains unclear. Electrophysiological and computational evidence from cortex and thalamus now indicates that the slow oscillation UP states and the ‘activated’ state of wakefulness are remarkably similar dynamic entities. This is consistent with behavioural experiments suggesting that slow oscillation UP states provide a context for the replay and possible consolidation of previous experience. In this scenario, the T-type Ca2+ channel-dependent bursts of action potentials that initiate each UP state in thalamocortical neurons, might act as triggers for synaptic and cellular plasticity in corticothalamic networks.
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影响因子：
7.8
作者：
Battaglia, FP;Sutherland, GR;Harris, KD
通讯作者：
Harris, KD
影响因子：
2.5
作者：
Compte, A;Sanchez-Vives, MV;Wang, XJ
通讯作者：
Wang, XJ
DOI：
10.1073/pnas.86.5.1698
发表时间：
1989-03-01
影响因子：
11.1
作者：
GRAY, CM;SINGER, W
通讯作者：
SINGER, W
影响因子：
25
作者：
Hahn, Thomas T. G.;Sakmann, Bert;Mehta, Mayank R.
通讯作者：
Mehta, Mayank R.
影响因子：
3.3
作者：
Achermann, P;Borbely, AA
通讯作者：
Borbely, AA