Nanotechnology for Cancer Therapy Based on Chemotherapy.
Nanotechnology for Cancer Therapy Based on Chemotherapy.
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基于化疗的癌症治疗纳米技术
DOI：
10.3390/molecules23040826
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发表时间：
2018-04-04
期刊：
影响因子：
--
通讯作者：
Tian ZM
中科院分区：
文献类型：
--
作者：
Zhao CY;Cheng R;Yang Z;Tian ZM
化疗已广泛应用于临床。然而，由于药物分布的非特异性、多药耐药（MDR）和肿瘤的异质性，化疗对肿瘤的治疗潜力严重不理想。因此，以纳米技术为媒介的化疗为基础的联合治疗已成为目前临床研究的趋势，可以显著提高治疗效率，而且对正常组织的副作用小。此外，为了实现对肿瘤的准确预诊断和实时监测，将诊断与治疗过程相结合的纳米治疗学研究是癌症治疗的一个有前景的领域。本文对近年来在化疗基础上的联合治疗进行了系统的综述。此外，作为当前癌症治疗的趋势，本文将简要举例说明基于化疗的治疗性纳米颗粒的进展。最后，将介绍目前在联合治疗和纳米治疗方面面临的挑战和改进建议。
Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.
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影响因子：
13.3
作者：
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通讯作者：
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影响因子：
4.9
作者：
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影响因子：
8
作者：
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通讯作者：
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