Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital.
Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital.
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在突尼斯医院中，菌群纹状体作为新兴的抗生素抗生素病原体的发生。
DOI：
10.1038/s41598-017-10081-y
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发表时间：
2017-08-28
影响因子：
4.6
通讯作者：
Navas J
中科院分区：
文献类型：
--
作者：
Alibi S;Ferjani A;Boukadida J;Cano ME;Fernández-Martínez M;Martínez-Martínez L;Navas J
纹状体棒状杆菌是一种医院内机会致病菌，越来越多地与广泛的人类感染相关，并且通常对几种抗生素具有耐药性。我们研究了63 C的敏感性。在2011-2014年期间，在Farhat-Hached医院，Sousse（突尼斯）分离的纹状体中，与属于主要临床相关类别的抗微生物剂的16种化合物的小组进行比较。所有菌株均对万古霉素、利奈唑胺和达托霉素敏感。丁胺卡那霉素和庆大霉素也显示出良好的活性（MIC 90分别= 1和2 mg/L）。对青霉素（82.5%）、克林霉素（79.4%）、头孢噻肟（60.3%）、红霉素（47.6%）、环丙沙星（36.5%）、氟沙星（34.9%）、利福平（25.4%）耐药率较高。63株分离株中有59株（93.7%）对至少一种化合物耐药，31株（49.2%）为多重耐药。在59个抗性菌株中，鉴定出29个抗性谱。纹状体大多数对氟喹诺酮类耐药的菌株显示出双突变，导致gyrA基因喹诺酮类耐药决定区的第87位和第91位氨基酸发生变化。52株青霉素耐药菌株的bla基因均为阳性，bla基因编码A类β-内酰胺酶。在63株C.纹状体，表明一些克隆已经在医院内传播。
Corynebacterium striatum is a nosocomial opportunistic pathogen increasingly associated with a wide range of human infections and is often resistant to several antibiotics. We investigated the susceptibility of 63 C. striatum isolated at the Farhat-Hached hospital, Sousse (Tunisia), during the period 2011–2014, to a panel of 16 compounds belonging to the main clinically relevant classes of antimicrobial agents. All strains were susceptible to vancomycin, linezolid, and daptomycin. Amikacin and gentamicin also showed good activity (MICs90 = 1 and 2 mg/L, respectively). High rates of resistance to penicillin (82.5%), clindamycin (79.4%), cefotaxime (60.3%), erythromycin (47.6%), ciprofloxacin (36.5%), moxifloxacin (34.9%), and rifampicin (25.4%) were observed. Fifty-nine (93.7%) out of the 63 isolates showed resistance to at least one compound and 31 (49.2%) were multidrug-resistant. Twenty-nine resistance profiles were distinguished among the 59 resistant C. striatum. Most of the strains resistant to fluoroquinolones showed a double mutation leading to an amino acid change in positions 87 and 91 in the quinolone resistance-determining region of the gyrA gene. The 52 strains resistant to penicillin were positive for the gene bla, encoding a class A β-lactamase. Twenty-two PFGE patterns were identified among the 63 C. striatum, indicating that some clones have spread within the hospital.
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影响因子：
11.8
作者：
Hahn WO;Werth BJ;Butler-Wu SM;Rakita RM
通讯作者：
Rakita RM
影响因子：
14.2
作者：
Magiorakos, A. -P.;Srinivasan, A.;Monnet, D. L.
通讯作者：
Monnet, D. L.
影响因子：
9.4
作者：
Brandenburg, AH;vanBelkum, A;Verbrugh, HA
通讯作者：
Verbrugh, HA
DOI：
10.1111/j.1469-0691.1997.tb00470.x
发表时间：
1997-02-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Martinez-Martinez, L.;Suarez, A.I.;Muniain, M. A.
通讯作者：
Muniain, M. A.
影响因子：
3.7
作者：
Navas, Jesus;Fernandez-Martinez, Marta;Martinez-Martinez, Luis
通讯作者：
Martinez-Martinez, Luis