Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases.
Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases.
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间充质干细胞来源的细胞外囊泡在女性生殖疾病中的治疗作用
DOI：
10.3389/fendo.2021.665645
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发表时间：
2021
影响因子：
5.2
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Liao Z;Liu C;Wang L;Sui C;Zhang H
子宫内粘连、卵巢功能不全和多囊卵巢综合征是影响女性生殖健康的重要因素。近年来，间充质干细胞来源的细胞外囊泡（mesenchymalstemcells derived-extracellularvesicles，MSC-EVs）因其来源于亲本细胞的生物学特性，以及较MSCs更高的生物学稳定性和更低的免疫原性而成为治疗这些疾病的潜在材料。EV是脂质双层复合物，通过将多个分子（例如蛋白质、微小RNA、脂质和细胞因子）转移到受体细胞而起到介体的作用。EVs对女性生殖系统疾病具有治疗作用，如修复损伤的子宫内膜、抑制子宫内膜纤维化、调节免疫和抗炎、抑制卵巢颗粒细胞凋亡等。虽然MSC-EV的潜在机制已达成共识，但已提出了几种理论，包括促进血管生成，调节免疫和降低氧化应激水平。在本研究中，我们总结了MSC-EV对IUA，POI和PCOS的功能的现有知识。鉴于MSC-EV在生殖健康方面的巨大潜力，所讨论的关键问题将为这一快速发展的领域提供新的见解。
Reproductive disorders, including intrauterine adhesion (IUA), premature ovarian insufficiency (POI), and polycystic ovary syndrome (PCOS), are great threats to female reproduction. Recently, mesenchymal stem cells derived–extracellular vesicles (MSC-EVs) have presented their potentials to cure these diseases, not only for the propensity ability they stemmed from the parent cells, but also for the higher biology stability and lower immunogenicity, compared to MSCs. EVs are lipid bilayer complexes, functional as mediators by transferring multiple molecules to recipient cells, such as proteins, microRNAs, lipids, and cytokines. EVs appeared to have a therapeutic effect on the female reproductive disorder, such as repairing injured endometrium, suppressing fibrosis of endometrium, regulating immunity and anti-inflammatory, and repressing apoptosis of granulosa cells (GCs) in ovaries. Although the underlying mechanisms of MSC-EVs have reached a consensus, several theories have been proposed, including promoting angiogenesis, regulating immunity, and reducing oxidate stress levels. In the current study, we summarized the current knowledge of functions of MSC-EVs on IUA, POI, and PCOS. Given the great potentials of MSC-EVs on reproductive health, the critical issues discussed will guide new insights in this rapidly expanding field.
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影响因子：
7.5
作者：
Diomede F;Gugliandolo A;Cardelli P;Merciaro I;Ettorre V;Traini T;Bedini R;Scionti D;Bramanti A;Nanci A;Caputi S;Fontana A;Mazzon E;Trubiani O
通讯作者：
Trubiani O
DOI：
10.1056/nejmoa1309635
发表时间：
2014-03-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Caburet S;Arboleda VA;Llano E;Overbeek PA;Barbero JL;Oka K;Harrison W;Vaiman D;Ben-Neriah Z;García-Tuñón I;Fellous M;Pendás AM;Veitia RA;Vilain E
通讯作者：
Vilain E
影响因子：
3.3
作者：
Ding, Dah-Ching;Shyu, Woei-Cherng;Lin, Shinn-Zong
通讯作者：
Lin, Shinn-Zong
影响因子：
4
作者：
Crain, Sarah K.;Robinson, Sally R.;Hoffman, Andrew M.
通讯作者：
Hoffman, Andrew M.
影响因子：
9.1
作者：
Ding, Lijun;Yan, Guijun;Sun, Haixiang
通讯作者：
Sun, Haixiang