Anticipation and violated expectation of pain are influenced by trait rumination: An fMRI study.
Anticipation and violated expectation of pain are influenced by trait rumination: An fMRI study.
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DOI：
10.3758/s13415-018-0644-y
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Juhasz G
中科院分区：
文献类型：
--
作者：
Kokonyei G;Galambos A;Edes AE;Kocsel N;Szabo E;Pap D;Kozak LR;Bagdy G;Juhasz G
反刍——作为一种反复关注与痛苦有关的感觉的稳定倾向——代表了一种跨诊断的风险因素。理论认为情绪信息加工的改变是反刍的关键机制。然而，尽管反刍过程中的期望被证明会影响情绪刺激的加工，但与反刍相关的预期过程的研究却很少。此外，目前还没有发表的研究调查与反刍有关的违反预期。在本研究中，我们使用以疼痛为非条件刺激的恐惧条件反射范式，对健康受试者（N = 30）的疼痛预期和感知的神经相关性进行了研究。采用10项反刍反应量表（RRS）评估反刍行为。广泛的大脑激活——延伸到颞叶、顶叶和枕叶，以及扣带皮层、脑岛和壳核的激活——显示出与反刍行为呈正相关，支持了我们的假设，即反刍行为影响预期过程。有趣的是，在违背预期的情况下（当一个意外的、非痛苦的刺激出现在疼痛线索之后，与一个预期的、痛苦的刺激出现在相同的疼痛线索之后），反刍和激活之间的负相关在后扣带皮层中被发现，后扣带皮层负责检测环境中的变化和随后的行为修正。我们的研究结果表明，反刍与疼痛感知和疼痛预期的神经反应增加有关，并可能恶化对意外遗漏的厌恶刺激的识别。因此，以反刍为目标的慢性疼痛认知行为治疗可能会产生有益的效果。本文的在线版本（10.3758/s13415-018-0644-y）包含补充内容，仅供授权用户使用。
Rumination – as a stable tendency to focus repetitively on feelings related to distress – represents a transdiagnostic risk factor. Theories suggest altered emotional information processing as the key mechanism of rumination. However, studies on the anticipation processes in relation to rumination are scarce, even though expectation in this process is demonstrated to influence the processing of emotional stimuli. In addition, no published study has investigated violated expectation in relation to rumination yet. In the present study we examined the neural correlates of pain anticipation and perception using a fear conditioning paradigm with pain as the unconditioned stimulus in healthy subjects (N = 30). Rumination was assessed with the 10-item Ruminative Response Scale (RRS). Widespread brain activation – extending to temporal, parietal, and occipital lobes along with activation in the cingulate cortex, insula, and putamen – showed a positive correlation with rumination, supporting our hypothesis that trait rumination influences anticipatory processes. Interestingly, with violated expectation (when an unexpected, non-painful stimulus follows a pain cue compared to when an expected, painful stimulus follows the same pain cue) a negative association between rumination and activation was found in the posterior cingulate cortex, which is responsible for change detection in the environment and subsequent behavioral modification. Our results suggest that rumination is associated with increased neural response to pain perception and pain anticipation, and may deteriorate the identification of an unexpected omission of aversive stimuli. Therefore, targeting rumination in cognitive behavioral therapy of chronic pain could have a beneficial effect. The online version of this article (10.3758/s13415-018-0644-y) contains supplementary material, which is available to authorized users.
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影响因子：
10.6
作者：
Christianson, John P.;Jennings, Joshua H.;Ragole, Thomas;Flyer, Johana G. N.;Benison, Alexander M.;Barth, Daniel S.;Watkins, Linda R.;Maier, Steven F.
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Maier, Steven F.
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影响因子：
4.2
作者：
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通讯作者：
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