The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.
The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.
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DOI：
10.4049/jimmunol.1900068
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发表时间：
2019-09-01
期刊：
影响因子：
--
通讯作者：
Sant'Angelo DB
中科院分区：
文献类型：
--
作者：
Zhang S;Vieth JA;Krzyzanowska A;Henry EK;Denzin LK;Siracusa MC;Sant'Angelo DB
Basophils are innate immune cells associated with Type 2 immunity, allergic reactions and host defense against parasite infections. In this study, we show that the transcription factor PLZF, which is known for its essential role in the function and development of several innate lymphocyte subsets, is also important for the myeloid-derived basophil lineage. PLZF-deficient mice had decreased numbers of basophil progenitors in the bone marrow and mature basophils in multiple peripheral tissues. Functionally, PLZF-deficient basophils were less responsive to IgE activation and produced reduced amounts of IL-4. The altered function of basophils resulted in a blunted Th2 T cell response to a protein allergen. Additionally, PLZF deficient basophils had reduced expression of the IL-18 receptor, which impacted migration to lungs. PLZF, therefore, is a major player in controlling Type 2 immune responses mediated not only by innate lymphocytes but also by myeloid derived cells.
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影响因子：
3.7
作者：
Eidson M;Wahlstrom J;Beaulieu AM;Zaidi B;Carsons SE;Crow PK;Yuan J;Wolchok JD;Horsthemke B;Wieczorek D;Sant'Angelo DB
通讯作者：
Sant'Angelo DB
影响因子：
30.5
作者：
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通讯作者：
Rothenberg EV
DOI：
10.1073/pnas.1423244112
发表时间：
2015-04-21
影响因子：
11.1
作者：
Constantinides, Michael G.;Gudjonson, Herman;Bendelac, Albert
通讯作者：
Bendelac, Albert
影响因子：
30.8
作者：
Barna, M;Hawe, N;Pandolfi, PP
通讯作者：
Pandolfi, PP
影响因子：
6
作者：
Kim S;Karasuyama H;Lopez AF;Ouyang W;Li X;Le Gros G;Min B
通讯作者：
Min B