Transcranial magnetic brain stimulation: therapeutic promises and scientific gaps.
Transcranial magnetic brain stimulation: therapeutic promises and scientific gaps.
复制标题
经颅磁脑刺激：治疗的承诺和科学差距。
DOI：
10.1016/j.pharmthera.2011.09.003
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发表时间：
2012-01
影响因子：
13.5
通讯作者：
Zimmermann, Trelawny
中科院分区：
文献类型：
--
作者：
Wassermann, Eric M.;Zimmermann, Trelawny
自1985年商业化以来，经颅磁刺激（TMS），一种通过头皮刺激大脑皮层神经元的技术，安全且不适感最小，吸引了科学家，临床医生和外行观察者的想象力。TMS最初是神经生理学家研究人类运动系统的实验室工具，现在在临床和基础神经科学中的应用越来越多。虽然我们了解它在系统层面上的许多影响，但对其行为的详细了解，特别是作为神经活动的调节剂，已经落后，主要是由于缺乏合适的非人类模型。然而，这些差距并没有阻止TMS在脑疾病中的治疗应用。在治疗抑郁症等疾病方面取得了一定的成功，美国食品和药物管理局已经批准TMS系统用于治疗。此外，还有一些关于治疗精神分裂症幻听、耳鸣、焦虑症、神经退行性疾病、轻偏瘫和疼痛综合征的小而有希望的数据。其他一些新兴的研究领域也存在。虽然TMS作为一种治疗方式的命运取决于持续的创新和实验，但经济和其他因素可能是决定性的。
Since its commercial advent in 1985, transcranial magnetic stimulation (TMS), a technique for stimulating neurons in the cerebral cortex through the scalp, safely and with minimal discomfort, has captured the imaginations of scientists, clinicians and lay observers. Initially a laboratory tool for neurophysiologists studying the human motor system, TMS now has a growing list of applications in clinical and basic neuroscience. Although we understand many of its effects at the system level, detailed knowledge of its actions, particularly as a modulator of neural activity, has lagged, due mainly to the lack of suitable non-human models. Nevertheless, these gaps have not blocked the therapeutic application of TMS in brain disorders. Moderate success has been achieved in treating disorders such as depression, where the U.S. Food and Drug Administration has cleared a TMS system for therapeutic use. In addition, there are small, but promising, bodies of data on the treatment of schizophrenic auditory hallucinations, tinnitus, anxiety disorders, neurodegenerative diseases, hemiparesis, and pain syndromes. Some other nascent areas of study also exist. While the fate of TMS as a therapeutic modality depends on continued innovation and experimentation, economic and other factors may be decisive.
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DOI：
10.4088/jcp.08m04638blu
发表时间：
2010-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Boggio PS;Rocha M;Oliveira MO;Fecteau S;Cohen RB;Campanhã C;Ferreira-Santos E;Meleiro A;Corchs F;Zaghi S;Pascual-Leone A;Fregni F
通讯作者：
Fregni F
影响因子：
--
作者：
Cotelli, Maria;Manenti, Rosa;Miniussi, Carlo
通讯作者：
Miniussi, Carlo
影响因子：
64.8
作者：
Cohen, LG;Celnik, P;Hallett, M
通讯作者：
Hallett, M
影响因子：
--
作者：
George, Mark S.;Lisanby, Sarah H.;Sackeim, Harold A.
通讯作者：
Sackeim, Harold A.
影响因子：
4.7
作者：
Fadini, Tommaso;Matthaeus, Lars;Nitsche, Michael A.
通讯作者：
Nitsche, Michael A.