Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells.
Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells.
复制标题
禽 H5N1 流感病毒在哺乳动物细胞中复制所需的病毒和宿主因子
DOI：
10.3390/v5061431
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发表时间：
2013-06-10
期刊：
影响因子：
--
通讯作者：
Sun B
中科院分区：
文献类型：
--
作者：
Zhang H;Hale BG;Xu K;Sun B
1997年，高致病性禽流感病毒H5 N1在香港首次出现并零星传播给人类后，我们逐渐认识到禽流感病毒有可能直接从鸟类传播给人类。了解导致哺乳动物感染禽流感病毒的基本病毒和细胞机制，对于制定预防和控制措施以应对未来可能的人类大流行至关重要。多种物理和功能性细胞屏障可以限制甲型流感病毒在新宿主物种中的感染，包括细胞膜、核被膜、核环境和先天性抗病毒反应。在这篇综述中，我们总结了目前的知识所需的禽H5 N1流感A病毒成功地建立感染哺乳动物细胞的病毒和宿主因素。我们专注于支持哺乳动物宿主限制的分子机制，以及禽流感病毒克服这些限制所必需的适应性突变。很可能还有更多的病毒和宿主决定因素有待发现，未来在这一领域的研究应提供新的和翻译的见解流感病毒-宿主相互作用的生物学。
Following the initial and sporadic emergence into humans of highly pathogenic avian H5N1 influenza A viruses in Hong Kong in 1997, we have come to realize the potential for avian influenza A viruses to be transmitted directly from birds to humans. Understanding the basic viral and cellular mechanisms that contribute to infection of mammalian species with avian influenza viruses is essential for developing prevention and control measures against possible future human pandemics. Multiple physical and functional cellular barriers can restrict influenza A virus infection in a new host species, including the cell membrane, the nuclear envelope, the nuclear environment, and innate antiviral responses. In this review, we summarize current knowledge on viral and host factors required for avian H5N1 influenza A viruses to successfully establish infections in mammalian cells. We focus on the molecular mechanisms underpinning mammalian host restrictions, as well as the adaptive mutations that are necessary for an avian influenza virus to overcome them. It is likely that many more viral and host determinants remain to be discovered, and future research in this area should provide novel and translational insights into the biology of influenza virus-host interactions.
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影响因子：
6.7
作者：
Carlson CM;Turpin EA;Moser LA;O'Brien KB;Cline TD;Jones JC;Tumpey TM;Katz JM;Kelley LA;Gauldie J;Schultz-Cherry S
通讯作者：
Schultz-Cherry S
影响因子：
5.4
作者：
Fodor, E;Smith, M
通讯作者：
Smith, M
影响因子：
64.8
作者：
Imai, Masaki;Watanabe, Tokiko;Hatta, Masato;Das, Subash C.;Ozawa, Makoto;Shinya, Kyoko;Zhong, Gongxun;Hanson, Anthony;Katsura, Hiroaki;Watanabe, Shinji;Li, Chengjun;Kawakami, Eiryo;Yamada, Shinya;Kiso, Maki;Suzuki, Yasuo;Maher, Eileen A.;Neumann, Gabriele;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
影响因子：
4.4
作者：
Costa T;Chaves AJ;Valle R;Darji A;van Riel D;Kuiken T;Majó N;Ramis A
通讯作者：
Ramis A
影响因子：
3.7
作者：
Gambaryan, A;Tuzikov, A;Klimov, A
通讯作者：
Klimov, A