COVID-19 cryptic transmission and genetic information blackouts: Need for effective surveillance policy to better understand disease burden.
COVID-19 cryptic transmission and genetic information blackouts: Need for effective surveillance policy to better understand disease burden.
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COVID-19神秘传播和遗传信息中断：需要有效的监测政策，以更好地了解疾病负担。
DOI：
10.1016/j.lanwpc.2021.100104
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Morita K
中科院分区：
文献类型：
--
作者：
Nabeshima T;Takazono T;Ashizawa N;Miyazaki T;Inoue S;Ngwe Tun MM;Izumikawa K;Mukae H;Moi ML;Morita K
我们饶有兴趣地阅读了SARS-CoV-2再感染病例中关于基因组信息在理解COVID-19真正负担方面的重要性[1]。在中国出现SARS-CoV-2之后，根据病毒序列分析，日本的最初病例是来自疫区的旅行相关病例。与全球COVID-19疫情一致，亚洲SARS-CoV-2分支在2020年3月初之前占主导地位[2]。然而，截至4月，随着欧洲分支（20 A，20 B，20 C）在日本成为优势分支，在接下来的几周内，没有关于亚洲分支（19 A和19 B）在当地传播的报道（图）。然而，我们的分析表明，亚洲分支仍然在流通，至少有两个菌株在当地得到证实。2020年7月分离的两株（日本/长崎-24_7-1/2020和日本/长崎-24_7-2/2020）均属于“减少型”亚洲分支19 B（图）。除了来自日本的628个分离株和全球分离的4981个菌株外，我们还观察到两个采样菌株都属于一个孤立的单系分支，其中该分支的下一个最接近的菌株是1月份分离的本地菌株（Japan/TY-WK-521/2020）（图1）。虽然在某些地理区域可能有有限的采样，但我们相信，这一独特的分支代表了从中国首次引入，随后是基础扩增和传播周期的持续社区维持。虽然暴发可能源于传入事件后的局部传播，但这些事件通常可以通过使用暴发进化枝的遗传学祖先病毒来追踪。在这种情况下，检测到日本特有的孤儿分支的持续传播表明，当地的传播可能仍然不存在。
We read with interest on the case of SARS-CoV-2 re-infection on the importance of genomic information in understanding the true burden of COVID-19 [1]. After the emergence of SARS-CoV-2 in China, initial cases in Japan were travel-associated cases from affected areas, as determined by the viral sequence analyses. In concordance with global COVID-19 epidemic, the Asian SARS-CoV-2 clades were dominant until the beginning of March, 2020 [2]. However, as of April, with the emergence of European clades (20A, 20B, 20C) as the dominant clade in Japan, there were no reports on local transmission of the Asian clades (19A and 19B) within the following weeks (figure). Our analysis however indicates the Asian clade remains in circulation, with at least two strains confirmed locally. Both strains (Japan/Nagasaki-24_7-1/2020 and Japan/Nagasaki-24_7-2/2020), isolated in July 2020, belonged to the “diminished” Asian clade, 19B (figure). In addition to the 628 isolates from Japan, and the 4981 globally isolated strains, we observed that both of the sampled strains were of an orphaned monophyletic clade, in which the next closest strain of this clade was a locally strain that was isolated in January (Japan/TY-WK-521/2020)(Fig. 1). While there may be limited sampling in certain geographical areas, we are confident that this distinct clade represents initial introduction from China, followed by basal amplification and persistent community maintenance of transmission cycle. While outbreaks may derive from local spread after introduction events, these events can generally be traced by using phylogenetically ancestral viruses of outbreak clades. In this context, the detection of persistent transmission of an orphan clade that is unique to Japan indicates local transmission that may remain un-
影响因子：
56.3
作者：
Tabata, Sakiko;Imai, Kazuo;Tamura, Kaku
通讯作者：
Tamura, Kaku
影响因子：
5.8
作者：
Hadfield, James;Megill, Colin;Neher, Richard A.
通讯作者：
Neher, Richard A.
影响因子：
2.2
作者：
Furuse, Yuki;Ko, Yura K.;Oshitani, Hitoshi
通讯作者：
Oshitani, Hitoshi