A role for T-lymphocytes in human breast cancer and in canine mammary tumors.
A role for T-lymphocytes in human breast cancer and in canine mammary tumors.
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DOI：
10.1155/2014/130894
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发表时间：
2014
影响因子：
--
通讯作者：
Queiroga FL
中科院分区：
文献类型：
--
作者：
Carvalho MI;Pires I;Prada J;Queiroga FL
肿瘤微环境中的慢性炎症在肿瘤发生中具有突出的作用，并且有利于恶性细胞的增殖和存活，促进血管生成和转移。乳腺肿瘤经常被免疫细胞的异质群体浸润，其中T淋巴细胞具有非常重要的作用。有趣的是，最近描述了人类和犬乳腺肿瘤中相似的炎性细胞浸润、细胞因子和趋化因子表达。然而，在这两个物种中，尽管所有的科学证据都表明T淋巴细胞的重要作用，但尚未获得关于T细胞依赖性免疫机制有效性的明确结论。在本综述中，我们描述了人类乳腺癌和犬乳腺肿瘤之间的肿瘤T淋巴细胞浸润的相似性，如TIL与乳腺肿瘤恶性程度的关系，CD 4 +/CD 8 + T细胞比例与低生存率的关联，Th 2细胞的作用促进肿瘤进展，以及大量Treg细胞与不良预后因素的关联。这种明显的平行性，加上狗在自然免疫系统的背景下发生自发性肿瘤的事实，凸显了狗作为人类乳腺癌免疫学研究的可能有用的生物模型。
Chronic inflammation in the tumor microenvironment has a prominent role in carcinogenesis and benefits the proliferation and survival of malignant cells, promoting angiogenesis and metastasis. Mammary tumors are frequently infiltrated by a heterogeneous population of immune cells where T-lymphocytes have a great importance. Interestingly, similar inflammatory cell infiltrates, cytokine and chemokine expression in humans and canine mammary tumors were recently described. However, in both species, despite all the scientific evidences that appoint for a significant role of T-lymphocytes, a definitive conclusion concerning the effectiveness of T-cell dependent immune mechanisms has not been achieved yet. In the present review, we describe similarities between human breast cancer and canine mammary tumors regarding tumor T-lymphocyte infiltration, such as relationship of TILs and mammary tumors malignancy, association of ratio CD4+/ CD8+ T-cells with low survival rates, promotion of tumor progression by Th2 cells actions, and association of great amounts of Treg cells with poor prognostic factors. This apparent parallelism together with the fact that dogs develop spontaneous tumors in the context of a natural immune system highlight the dog as a possible useful biological model for studies in human breast cancer immunology.
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DOI：
10.1186/bcr554
发表时间：
2003
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Ben-Baruch A
通讯作者：
Ben-Baruch A
影响因子：
3.8
作者：
Estrela-Lima, Alessandra;Araujo, Marcio S. S.;Cassali, Geovanni D.
通讯作者：
Cassali, Geovanni D.
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
3.8
作者：
Campbell, MJ;Scott, J;Esserman, LJ
通讯作者：
Esserman, LJ
影响因子：
7.3
作者：
Cockwell, P;Chakravorty, SJ;Savage, COS
通讯作者：
Savage, COS