Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells.
Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells.
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皮肤是人体最大的器官，由多种细胞类型、非细胞成分和细胞外基质组成。随着衰老，作为细胞外基质一部分的分子经历定性和定量的变化，并且可以看到诸如皮肤紧致度或皱纹的损失的影响。衰老过程引起的变化不仅影响皮肤表面，还延伸到皮肤附属物，如毛囊。在本研究中，研究了海洋来源的海藻酸钠、L-岩藻糖和硫酸软骨素二糖支持皮肤和头发健康并最大限度地减少内在和外在衰老影响的能力。研究了受试样品通过刺激自然过程、细胞增殖和细胞外基质组分胶原蛋白、弹性蛋白或糖胺聚糖的产生来预防皮肤和毛发不良变化的潜力。测试的化合物，L-岩藻糖和硫酸软骨素二糖，支持皮肤和头发健康，特别是在抗衰老作用方面。所获得的结果表明，两种成分支持和促进真皮成纤维细胞和真皮乳头细胞的增殖，为细胞提供硫酸化二糖GAG结构单元的供应，通过HDFa增加ECM分子产生（胶原蛋白和弹性蛋白），并支持毛发周期的生长阶段（毛发生长期）。
The skin is the largest organ of the human body, composed of a diverse range of cell types, non-cellular components, and an extracellular matrix. With aging, molecules that are part of the extracellular matrix undergo qualitative and quantitative changes and the effects, such as a loss of skin firmness or wrinkles, can be visible. The changes caused by the aging process do not only affect the surface of the skin, but also extend to skin appendages such as hair follicles. In the present study, the ability of marine-derived saccharides, L-fucose and chondroitin sulphate disaccharide, to support skin and hair health and minimize the effects of intrinsic and extrinsic aging was investigated. The potential of the tested samples to prevent adverse changes in the skin and hair through stimulation of natural processes, cellular proliferation, and production of extracellular matrix components collagen, elastin, or glycosaminoglycans was investigated. The tested compounds, L-fucose and chondroitin sulphate disaccharide, supported skin and hair health, especially in terms of anti-aging effects. The obtained results indicate that both ingredients support and promote the proliferation of dermal fibroblasts and dermal papilla cells, provide cells with a supply of sulphated disaccharide GAG building blocks, increase ECM molecule production (collagen and elastin) by HDFa, and support the growth phase of the hair cycle (anagen).
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