Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature.
Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature.
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DOI：
10.1007/s10456-009-9135-7
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发表时间：
2009
期刊：
影响因子：
9.8
通讯作者：
Brown JM
中科院分区：
文献类型：
--
作者：
Ahn GO;Brown JM
越来越多的证据表明骨髓来源的细胞对于肿瘤中血管形成（新血管形成）的重要性，其可以通过两种机制发生：血管生成和血管发生。血管生成是由肿瘤附近现有血管的增殖和发芽引起的，而血管生成被认为是由循环细胞的募集引起的，循环细胞主要来源于骨髓，并且血管从这些细胞重新克隆形成。虽然骨髓来源的细胞对于新生血管形成至关重要，但目前的证据表明这些细胞对现有血管的促进作用，而不是肿瘤中的新生血管形成。这被认为是由于这些细胞的高度促血管生成特征。骨髓来源的细胞是异质的，由许多不同的细胞类型组成，包括内皮祖细胞、髓样细胞、淋巴细胞和间充质细胞。这些细胞在特定肿瘤微环境的影响下高度协调，该微环境根据肿瘤类型而变化，从而严格调节肿瘤中的新血管形成。在这篇综述中，我们通过概述这些细胞分泌的促进肿瘤血管生成和血管生成的一些基本促血管生成细胞因子，突出了这些细胞类型的一些最新发现。
Increasing evidence suggests the importance of bone marrow-derived cells for blood vessel formation (neovascularization) in tumors, which can occur in two mechanisms: angiogenesis and vasculogenesis. Angiogenesis results from proliferation and sprouting of existing blood vessels close to the tumor, while vasculogenesis is believed to arise from recruitment of circulating cells, largely derived from the bone marrow, and de novo clonal formation of blood vessels from these cells. Although bone marrow-derived cells are crucial for neovascularization, current evidence suggests a promotional role of these cells on the existing blood vessels rather than de novo neovascularization in tumors. This is believed to be due to the highly proangiogenic features of these cells. The bone marrow-derived cells are heterogeneous, consisting of many different cell types including endothelial progenitor cells, myeloid cells, lymphocytes, and mesenchymal cells. These cells are highly orchestrated under the influence of the specific tumor microenvironment, which varies depending on the tumor type, thereby tightly regulating neovascularization in the tumors. In this review, we high-light some of the recent findings on each of these cell types by outlining some of the essential proangiogenic cytokines that these cells secrete to promote tumor angiogenesis and vasculogenesis.
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