HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers.
HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers.
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DOI：
10.1037/abn0000316
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发表时间：
2017-11
影响因子：
4.6
通讯作者：
Gibb BE
中科院分区：
文献类型：
--
作者：
Feurer C;McGeary JE;Knopik VS;Brick LA;Palmer RH;Gibb BE
虽然抑郁母亲的后代患抑郁症的风险增加，但并非所有这些儿童都会患抑郁症，这突出表明需要确定特定的环境和遗传风险调节因子。本研究的目的是研究与调节下丘脑-垂体-肾上腺（HPA）轴相关的遗传多态性的综合影响，作为抑郁症母亲后代抑郁症状的环境压力和预期变化之间关系的潜在调节剂。参与者是238名母亲和子女的二对夫妇，他们是根据母亲在青少年一生中的抑郁症病史（存在与不存在）从社区招募的。母亲和青年每6个月完成一次评估，持续两年（共5次）。结果表明，抑郁症母亲的后代在随访期间表现出最大的抑郁症状增加是那些具有较高的HPA多位点遗传谱分数和经历了最高水平的人际压力。这些关系是显着的人际压力，并没有观察到非人际压力。这些研究结果表明，HPA多位点遗传图谱评分可能是抑郁母亲后代应激反应和抑郁风险的重要遗传标记。他们还强调，人际压力是这些高危青年的一个潜在的可改变的风险因素。
Although offspring of depressed mothers are at an increased risk for depression themselves, not all of these children develop depression, highlighting the need to identify specific environmental and genetic moderators of risk. The goal of this study was to examine the aggregate influence of genetic polymorphisms associated with the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as a potential moderator of the relation between environmental stress and prospective changes in depressive symptoms for offspring of depressed mothers. Participants were 238 mother-offspring dyads recruited from the community based on the mother’s lifetime history of major depression during the youth’s lifetime (present vs. absent). Mothers and youth completed assessments every 6 months for 2 years (5 total). Results indicated that offspring of depressed mothers showing the greatest increases in depressive symptoms during the follow up were those who had higher HPA multilocus genetic profile scores and who experienced the highest levels of interpersonal stress. These relations were significant for interpersonal stress and were not observed for non-interpersonal stress. These findings suggest that HPA multilocus genetic profile scores may be important genetic markers of stress reactivity and depression risk for offspring of depressed mothers. They also highlight interpersonal stress as a potentially modifiable risk factor for these high-risk youth.
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皮质激素受体基因的单核苷酸多态性与青少年标准化社会压力测试的心率和皮质醇反应之间没有关联：TRAILS 研究。
影响因子：
2.6
作者：
Bouma, Esther M. C.;Riese, Harriette;Nolte, Ilja M.;Oosterom, Elvira;Verhulst, Frank C.;Ormel, Johan;Oldehinkel, Albertine J.
通讯作者：
Oldehinkel, Albertine J.
影响因子：
3.3
作者：
Engels, William R.
通讯作者：
Engels, William R.
影响因子：
3.7
作者：
Adam, Emma K.;Doane, Leah D.;Zinbarg, Richard E.;Mineka, Susan;Craske, Michelle G.;Griffith, James W.
通讯作者：
Griffith, James W.
影响因子：
3.3
作者：
Cicchetti D;Rogosch FA;Oshri A
通讯作者：
Oshri A
DOI：
10.1016/j.jaac.2014.10.010
发表时间：
2015-01
影响因子：
13.3
作者：
Avenevoli, Shelli;Swendsen, Joel;He, Jian-Ping;Burstein, Marcy;Merikangas, Kathleen Ries
通讯作者：
Merikangas, Kathleen Ries