Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs.
Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs.
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DOI：
10.1111/add.14393
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Degenhardt L
中科院分区：
文献类型：
--
作者：
Grebely J;Larney S;Peacock A;Colledge S;Leung J;Hickman M;Vickerman P;Blach S;Cunningham EB;Dumchev K;Lynskey M;Stone J;Trickey A;Razavi H;Mattick RP;Farrell M;Dore GJ;Degenhardt L
最近注射毒品的人是努力实现丙型肝炎病毒（HCV）消除的优先人群。这项研究估计了全球、区域和国家各级最近注射吸毒的HCV感染者的患病率和人数，以及最近注射吸毒的HCV感染者在所有HCV感染者中的比例。使用了一项关于注射吸毒和最近（前一年）注射吸毒者中HCV抗体流行率的全球系统性审查的数据，以估计感染HCV的最近注射吸毒者的流行率和人数。这些数据与全球HCV流行率的系统性综述相结合，以估计最近注射毒品使用者在所有HCV感染者中的比例。据估计，全球有610万[95%不确定区间（UI）3.4-9.2]年龄在15-64岁的近期注射吸毒者感染HCV病毒血症患病率为39.2%; UI 31.6-47.0），东亚和东南亚的人数最多（150万，UI 1.0-2.1）、东欧（150万，UI 0.7-2.4）和北美（100万，UI 0.4-1.7）。据估计，近期注射吸毒者占全球所有HCV感染的8.5%（UI 4.6-13.1），其中北美（30.5%，UI 11.7-56.7），拉丁美洲（22.0%，UI 15.3-30.4）和东欧（17.9%，UI 8.2-30.9）的比例最高。虽然约40%的近期注射毒品使用者是HCV感染者，全球近9%的HCV感染发生在近期注射毒品使用者中，但全球范围内的差异很大。
People who have recently injected drugs are a priority population in efforts to achieve hepatitis C virus (HCV) elimination. This study estimated the prevalence and number of people with recent injecting drug use living with HCV, and the proportion of people with recent injecting drug use among all people living with HCV infection at global, regional, and country-levels. Data from a global systematic review of injecting drug use and HCV antibody prevalence among people with recent (previous year) injecting drug use were used to estimate the prevalence and number of people with recent injecting drug use living with HCV. These data were combined with a systematic review of global HCV prevalence to estimate the proportion of people with recent injecting drug use among all people living with HCV. There are an estimated 6.1 million [95% uncertainty interval (UI) 3.4–9.2] people with recent injecting drug use aged 15–64 years living with HCV globally (39.2% viraemic prevalence; UI 31.6–47.0), with the greatest numbers in East and Southeast Asia (1.5 million, UI 1.0–2.1), Eastern Europe (1.5 million, UI 0.7–2.4), and North America (1.0 million, UI 0.4–1.7). People with recent injecting drug use comprise an estimated 8.5% (UI 4.6–13.1) of all HCV infections globally, with the greatest proportions in North America (30.5%, UI 11.7–56.7), Latin America (22.0%, UI 15.3–30.4), and Eastern Europe (17.9%, UI 8.2–30.9). Although about forty-percent of people with recent injecting drug use are living with HCV and almost nine percent of all HCV infections globally occur among people with recent injecting drug use, there is wide variation globally.
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影响因子：
168.9
作者：
Nelson, Paul K.;Mathers, Bradley M.;Cowie, Benjamin;Hagan, Holly;Des Jarlais, Don;Horyniak, Danielle;Degenhardt, Louisa
通讯作者：
Degenhardt, Louisa
影响因子：
13.5
作者：
Grebely, Jason;Page, Kimberly;Sacks-Davis, Rachel;van der Loeff, Maarten Schim;Rice, Thomas M.;Bruneau, Julie;Morris, Meghan D.;Hajarizadeh, Behzad;Amin, Janaki;Cox, Andrea L.;Kim, Arthur Y.;McGovern, Barbara H.;Schinkel, Janke;George, Jacob;Shoukry, Naglaa H.;Lauer, Georg M.;Maher, Lisa;Lloyd, Andrew R.;Hellard, Margaret;Dore, Gregory J.;Prins, Maria
通讯作者：
Prins, Maria
影响因子：
4.4
作者：
Bajis, Sahar;Dore, Gregory J.;Grebely, Jason
通讯作者：
Grebely, Jason
影响因子：
3.7
作者：
Wiessing L;Ferri M;Grady B;Kantzanou M;Sperle I;Cullen KJ;EMCDDA DRID group;Hatzakis A;Prins M;Vickerman P;Lazarus JV;Hope VD;Matheï C
通讯作者：
Matheï C
影响因子：
168.9
作者：
Mathers, Bradley M.;Degenhardt, Louisa;Mattick, Richard P.
通讯作者：
Mattick, Richard P.