Cholinergic enhancement augments magnitude and specificity of visual perceptual learning in healthy humans.
Cholinergic enhancement augments magnitude and specificity of visual perceptual learning in healthy humans.
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DOI：
10.1016/j.cub.2010.08.027
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发表时间：
2010-10-12
期刊：
影响因子：
9.2
通讯作者：
Silver, Michael A.
中科院分区：
文献类型：
--
作者：
Rokem, Ariel;Silver, Michael A.
通过经验学习是适应新任务和陌生环境的能力的基础。然而，学习必须加以调节，以便有选择地对环境的相关方面进行编码。乙酰胆碱（Acetylcholine，ACh）通过增强感觉皮层神经元对行为刺激的反应来调节学习。在这项研究中，我们用胆碱酯酶抑制剂多奈哌齐（商品名：安理申）增加健康人大脑中ACh的突触水平，并测量这种胆碱能增强对视觉感知学习的影响。每个受试者完成两个为期五天的运动方向辨别任务训练课程，一次是在每次训练前服用5 mg多奈哌齐，一次是服用安慰剂。我们发现，胆碱能增强知觉学习的刺激具有相同的运动方向和训练过程中使用的视野位置。此外，多奈哌齐下的知觉学习对训练的运动方向和视野位置更具选择性。这些结果，结合以往的研究表明，增加神经元的选择性胆碱能增强后，建议一个可能的机制，乙酰胆碱增强神经可塑性的直接活动的神经元编码的行为相关的刺激功能的人口。
Learning through experience underlies the ability to adapt to novel tasks and unfamiliar environments. However, learning must be regulated so that relevant aspects of the environment are selectively encoded. Acetylcholine (ACh) has been suggested to regulate learning by enhancing the responses of sensory cortical neurons to behaviorally-relevant stimuli. In this study, we increased synaptic levels of ACh in the brains of healthy human subjects with the cholinesterase inhibitor donepezil (trade name: Aricept) and measured the effects of this cholinergic enhancement on visual perceptual learning. Each subject completed two five-day courses of training on a motion direction discrimination task, once while ingesting 5 mg of donepezil before every training session and once while placebo was administered. We found that cholinergic enhancement augmented perceptual learning for stimuli having the same direction of motion and visual field location used during training. In addition, perceptual learning under donepezil was more selective to the trained direction of motion and visual field location. These results, combined with previous studies demonstrating an increase in neuronal selectivity following cholinergic enhancement, suggest a possible mechanism by which ACh augments neural plasticity by directing activity to populations of neurons that encode behaviorally-relevant stimulus features.
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影响因子：
64.8
作者：
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者：
Thiele, A.
影响因子：
3.3
作者：
Arnold, HM;Burk, JA;Bruno, JP
通讯作者：
Bruno, JP
影响因子：
9.2
作者：
Furmanski, CS;Schluppeck, D;Engel, SA
通讯作者：
Engel, SA
影响因子：
56.9
作者：
GREUEL, JM;LUHMANN, HJ;SINGER, W
通讯作者：
SINGER, W
影响因子：
56.9
作者：
BALL, K;SEKULER, R
通讯作者：
SEKULER, R