Optimum health and inhibition of cancer progression by microbiome and resveratrol.
Optimum health and inhibition of cancer progression by microbiome and resveratrol.
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DOI：
10.2741/4904
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Mishra MK
中科院分区：
文献类型：
--
作者：
Stokes Iii J;Vinayak S;Williams J;Malik S;Singh R;Manne U;Owonikoko TK;Mishra MK
白藜芦醇 (RES) 是一种天然存在的多酚，存在于水果、绿叶蔬菜和花生中。这种多功能化合物具有强大的再生、抗氧化和抗癌特性，是在植物中产生的，特别是在应对应激刺激时。通过多种机制，包括基因和蛋白质的调节，RES 抑制病原菌的生长和癌症的发展。肠道在营养同化、新陈代谢、免疫和癌症消退中发挥着重要作用，内源性微生物群可以保护宿主免受入侵细菌的侵害，从而促进各种疾病的进展。短链脂肪酸（SFCA）是胃肠道微生物发酵的副产品。天然微生物群可调节内部稳态，影响宿主免疫细胞的活性，并通过植物性饮食中产生的 SCFA 的作用来消退某些癌症。本综述显示了膳食成分和肠道微生物活性在确保宿主最佳健康方面的相关性。
Resveratrol (RES) is a naturally occurring polyphenol found in fruits, green leafy vegetables, and peanuts. This versatile compound, which has potent regenerative, anti-oxidative, and cancer-fighting properties, is produced in plants, particularly in response to stress stimuli. By various mechanisms, including regulation of genes and proteins, RES inhibits the growth of pathogenic bacteria and the development of cancers. The gut has a prominent role in nutrient assimilation, metabolism, immunity, and cancer regression, and the endogenous microbiome protects the host from invasive bacteria that facilitate the progression of various diseases. Short-chain fatty acids (SFCAs) are the byproducts of microbial fermentation in the gastrointestinal tract. Native microflora regulates internal homeostasis, influence the activity of host immune cells, and regress some cancers via the action of SCFAs produced from a plant-based diet. This review shows the relevance of dietary constituents and gut microbial activity in ensuring optimal health of the host.
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