Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats
Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats
复制标题
曲美他嗪对大鼠肠缺血再灌注损伤60 min的细胞保护作用
DOI：
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发表时间：
1999
影响因子：
3.1
通讯作者：
H. Bayramoǧlu
中科院分区：
文献类型：
--
作者：
C. Tetik;Akın Ozden;N. Çalli;A. Bilgihan;B. Bostancı;Ö. Yis;H. Bayramoǧlu
曲美他嗪（TMZ）是一种有效的抗氧化剂，已被用于保护心肌、肝脏和肾脏免受缺血再灌注（IR）损伤。我们研究了细胞抗缺血剂和自由基清除剂TMZ对大鼠60分钟热肠IR损伤的影响。将Sprague-Dawley大鼠分为三组：假手术组（无IR损伤，n = 8）、缺血对照组（对照，n = 8）和TMZ治疗组（3 mg/kg，n = 8）。再灌注120 min后检测丙二醛（MDA）水平、髓过氧化物酶（MPO）活性和粘膜损伤。与假手术组相比，对照组MDA含量和MPO活性明显升高，组织病理学损害明显加重（P < 0.05）。TMZ组MDA含量和MPO活性均低于对照组（P < 0.05），组织病理学损害轻于对照组（P < 0.05）。TMZ处理显著抑制粘膜组织中脂质过氧化产物和中性粒细胞的积累。我们得出结论，TMZ预处理大鼠肠缺血减弱，但不能防止，组织学损伤。
Abstract Trimetazidine (TMZ), a potent antioxidant agent, has been used to protect the myocardium, liver and kidney from ischemia reperfusion (IR) injury. We investigated the effect of TMZ, a cellular anti-ischemic agent and a free radical scavenger, on 60 min of warm intestinal IR injury in rats. Sprague-Dawley rats were divided into three groups: a sham-operated group (no IR injury, n = 8), an ischemic control group (control, n = 8), and a TMZ-treated group (3 mg/kg, n = 8). Malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, and mucosal damage were investigated after 120 min of reperfusion. MDA levels and MPO activity were more elevated and histopathological damage more severe in the control group than in the sham group (P < 0.05). MDA levels and MPO activity were lower and there was less histopathological damage in the TMZ group than in the control group (P < 0.05). Accumulation of lipid peroxidation products and neutrophils in mucosal tissues were significantly inhibited by TMZ treatment. We conclude that pretreatment of rats with TMZ before intestinal ischemia attenuates but does not prevent, histological damage.
DOI：
10.1152/ajpgi.1990.258.2.g185
发表时间：
1990-02
期刊：
The American journal of physiology
影响因子：
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作者：
B. Zimmerman;M. Grisham;D. Granger
通讯作者：
B. Zimmerman;M. Grisham;D. Granger
影响因子：
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作者：
GRISHAM, MB;HERNANDEZ, LA;GRANGER, DN
通讯作者：
GRANGER, DN
影响因子：
29.4
作者：
KUBES, P;HUNTER, J;GRANGER, DN
通讯作者：
GRANGER, DN