Immune Cells as Critical Regulators of Steroidogenesis in the Testis and Beyond.
Immune Cells as Critical Regulators of Steroidogenesis in the Testis and Beyond.
复制标题
免疫细胞作为睾丸及其他部位类固醇生成的关键调节因子。
DOI：
10.3389/fendo.2022.894437
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发表时间：
2022
影响因子：
5.2
通讯作者：
DeFalco, Tony
中科院分区：
文献类型：
--
作者：
Gu, Xiaowei;Li, Shu-Yun;Matsuyama, Satoko;DeFalco, Tony
类固醇生成是胚胎发育、生殖和成年健康的重要生物学过程。虽然特定的腺细胞，如睾丸中的Leydig细胞，传统上被认为是类固醇激素产生的主要参与者，但还有其他细胞类型有助于类固醇生成的过程。特别是，免疫细胞通常是产生类固醇激素所需的细胞生态位的重要组成部分。几十年来，研究报道睾丸巨噬细胞和间质细胞密切相关，并表现出对其他细胞类型的依赖性，以促进其正常发育;然而，巨噬细胞和间质细胞之间功能关系的机制尚不清楚。在睾丸之外，在某些情况下，免疫细胞本身，如某些类型的淋巴细胞，能够产生类固醇激素，从而突出了类固醇生成的复杂性和多样性。在这篇综述中，我们将描述免疫细胞是如何在睾丸和腺外位置类固醇生成的关键调节剂，以及讨论这一领域的研究如何提供机会，发现类固醇激素生产的新见解。
Steroidogenesis is an essential biological process for embryonic development, reproduction, and adult health. While specific glandular cells, such as Leydig cells in the testis, are traditionally known to be the principal players in steroid hormone production, there are other cell types that contribute to the process of steroidogenesis. In particular, immune cells are often an important component of the cellular niche that is required for the production of steroid hormones. For several decades, studies have reported that testicular macrophages and Leydig cells are intimately associated and exhibit a dependency on the other cell type for their proper development; however, the mechanisms that underlie the functional relationship between macrophages and Leydig cells are unclear. Beyond the testis, in certain instances immune cells themselves, such as certain types of lymphocytes, are capable of steroid hormone production, thus highlighting the complexity and diversity that underlie steroidogenesis. In this review we will describe how immune cells are critical regulators of steroidogenesis in the testis and in extra-glandular locations, as well as discuss how this area of research offers opportunities to uncover new insights into steroid hormone production.
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影响因子：
3.3
作者：
Aizawa, Katsuji;Iemitsu, Motoyuki;Mesaki, Noboru
通讯作者：
Mesaki, Noboru
DOI：
10.1111/febs.15848
发表时间：
2022-05
期刊：
The FEBS journal
影响因子：
--
作者：
Gu X;Li SY;DeFalco T
通讯作者：
DeFalco T
影响因子：
8.8
作者：
DeFalco T;Potter SJ;Williams AV;Waller B;Kan MJ;Capel B
通讯作者：
Capel B
影响因子：
3.5
作者：
Chadwick, Jessica A.;Swager, Sarah A.;Rafael-Fortney, Jill A.
通讯作者：
Rafael-Fortney, Jill A.
影响因子：
5.8
作者：
Escobar, J. C.;Patel, S. S.;Carr, B. R.
通讯作者：
Carr, B. R.