Immune and vascular contributions to organogenesis of the testis and ovary.
Immune and vascular contributions to organogenesis of the testis and ovary.
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DOI：
10.1111/febs.15848
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
DeFalco T
中科院分区：
文献类型：
--
作者：
Gu X;Li SY;DeFalco T
性腺发育是一个高度调节的过程，协调细胞特化和形态发生，以产生生育所需的性别特异性器官结构，如睾丸曲细精管和卵泡。虽然性别决定发生在专门的性腺支持细胞中，但性分化在整个器官中都很明显，包括在含有免疫细胞和脉管系统的间质区室中。虽然免疫细胞和血管细胞在组织生长和体内平衡过程中的支持作用一直受到传统的赞赏，但越来越多的证据支持这些细胞类型是性腺性二态形态发生的关键驱动因素。髓样免疫细胞，如巨噬细胞，对于性腺发生和生育力的多个方面是必不可少的，包括在生命的不同阶段形成和维持两性的性腺脉管系统。虽然脉管系统长期以来被认为是支持器官生长和作为子宫内性腺性类固醇的输出机制，但它也是胎儿睾丸形态发生和分化的重要组成部分;此外，它对卵巢黄体功能和维持妊娠至关重要。这些发现指向一个新的范例，其中免疫细胞和血管是性分化和器官发生的组成部分。在这篇综述中，我们讨论了该领域的状态关于睾丸和卵巢的器官形成过程中的免疫和血管细胞的不同作用，并强调了该领域的突出问题，可以刺激新的研究这些以前未被充分认识的成分的性腺。
Gonad development is a highly regulated process that coordinates cell specification and morphogenesis to produce sex-specific organ structures that are required for fertility, such as testicular seminiferous tubules and ovarian follicles. While sex determination occurs within specialized gonadal supporting cells, sexual differentiation is evident throughout the entire organ, including within the interstitial compartment, which contains immune cells and vasculature. While immune and vascular cells have been traditionally appreciated for their supporting roles during tissue growth and homeostasis, an increasing body of evidence supports the idea that these cell types are critical drivers of sexually dimorphic morphogenesis of the gonad. Myeloid immune cells, such as macrophages, are essential for multiple aspects of gonadogenesis and fertility, including for forming and maintaining gonadal vasculature in both sexes at varying stages of life. While vasculature is long known for supporting organ growth and serving as an export mechanism for gonadal sex steroids in utero, it is also an important component of fetal testicular morphogenesis and differentiation; additionally, it is vital for ovarian corpus luteal function and maintenance of pregnancy. These findings point toward a new paradigm in which immune cells and blood vessels are integral components of sexual differentiation and organogenesis. In this review we discuss the state of the field regarding the diverse roles of immune and vascular cells during organogenesis of the testis and ovary and highlight outstanding questions in the field that could stimulate new research into these previously underappreciated constituents of the gonad.
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影响因子：
1.7
作者：
Abdulrahman, Noof;Fair, Trudee
通讯作者：
Fair, Trudee
影响因子：
30.5
作者：
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影响因子：
7.3
作者：
Brown MB;von Chamier M;Allam AB;Reyes L
通讯作者：
Reyes L
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影响因子：
9
作者：
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通讯作者：
Liu, Yi-Xun
DOI：
10.1111/j.1439-0442.1998.tb00819.x
发表时间：
1998-05-01
期刊：
JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE
影响因子：
--
作者：
Anton, F;Morales, C;Gaytan, F
通讯作者：
Gaytan, F