Monitoring Cell Plasma Membrane Polarity by a NIR Fluorescence Probe with Unexpected Cell Plasma Membrane-Targeting Ability.
Monitoring Cell Plasma Membrane Polarity by a NIR Fluorescence Probe with Unexpected Cell Plasma Membrane-Targeting Ability.
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通过具有意外的细胞质膜靶向能力的NIR荧光探针监测细胞质膜极性。
DOI：
10.1021/acsomega.2c05997
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发表时间：
2022-12-20
期刊：
影响因子：
4.1
通讯作者：
Li, Hongyu
中科院分区：
文献类型：
--
作者：
Liu, Jiaojiao;Liu, Mei;Meng, Fancheng;Lv, Jiajia;Yang, Mingyan;Gao, Jie;Wei, Gang;Yuan, Zeli;Li, Hongyu
The cell plasma membrane, the natural barrier of a cell, plays critical roles in a mass of cell physiological and pathological processes. Therefore, revealing and monitoring the local status of the cell plasma membrane are of great significance. Herein, using a near-infrared (NIR) fluorescence probe BTCy, microenvironmental polarity in the cell plasma membrane was in situ monitored. BTCy showed sensitive and selective fluorescence decrease response at 706 nm with the increase of polarity as its polarity-responsive D−π–A structure. Most importantly, BTCy showed unexpected cell plasma membrane-targeting ability, probably due to its amphiphilic structure. With BTCy, the distinguishing imaging of cancer and normal cells was done, in which cancer cells exhibited significantly stronger signals due to their lower cell plasma membrane polarity. In addition, with the imaging of BTCy, the ferroptosis process was revealed with no significant cell plasma membrane polarity variation for the first time. Furthermore, BTCy was employed for in vivo imaging of tumor tissue in the 4T1-tumor-bearing mice. The polarity-responsive and cell plasma membrane-targeting properties of BTCy make it a useful tool for monitoring cell plasma membrane polarity variation, providing an efficient and simple method for tumor diagnosis.
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DOI：
10.1002/anie.201802796
发表时间：
2018-07-16
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Jiménez-Sánchez A;Lei EK;Kelley SO
通讯作者：
Kelley SO
影响因子：
14.9
作者：
Narayanaswamy N;Das S;Samanta PK;Banu K;Sharma GP;Mondal N;Dhar SK;Pati SK;Govindaraju T
通讯作者：
Govindaraju T
影响因子：
5.7
作者：
Ashoka, Anila Hoskere;Ashokkumar, Pichandi;Klymchenko, Andrey S.
通讯作者：
Klymchenko, Andrey S.
影响因子：
15
作者：
Danylchuk, Dmytro, I;Jouard, Pierre-Henri;Klymchenko, Andrey S.
通讯作者：
Klymchenko, Andrey S.
活性氧和粘度双功能荧光探针的设计、合成及应用
DOI：
10.1016/j.saa.2020.119059
发表时间：
2021-02-05
影响因子：
4.4
作者：
Li, Hongyu;Liu, Ya;Ma, Huimin
通讯作者：
Ma, Huimin