Optimization of cerebral organoids: a more qualified model for Alzheimer's disease research.
Optimization of cerebral organoids: a more qualified model for Alzheimer's disease research.
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DOI：
10.1186/s40035-021-00252-3
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发表时间：
2021-08-09
影响因子：
12.6
通讯作者：
Yao Y
中科院分区：
文献类型：
--
作者：
Bi FC;Yang XH;Cheng XY;Deng WB;Guo XL;Yang H;Wang Y;Li J;Yao Y
Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis.目前AD的动物和细胞模型无法满足AD的研究需求。 However, recent three-dimensional (3D) cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of AD. In this review, we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models, and propose possible solutions, in order to improve their application in AD research.还讨论了与人类大脑类器官相关的伦理问题。 We also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.
Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to meet research needs for AD. However, recent three-dimensional (3D) cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of AD. In this review, we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models, and propose possible solutions, in order to improve their application in AD research. Ethical concerns associated with human cerebral organoids are also discussed. We also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.
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影响因子：
3.9
作者：
Calvani R;Picca A;Lo Monaco MR;Landi F;Bernabei R;Marzetti E
通讯作者：
Marzetti E
影响因子：
3.1
作者：
Balducci, Claudia;Forloni, Gianluigi
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Forloni, Gianluigi
影响因子：
8.8
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Arber C;Lovejoy C;Harris L;Willumsen N;Alatza A;Casey JM;Lines G;Kerins C;Mueller AK;Zetterberg H;Hardy J;Ryan NS;Fox NC;Lashley T;Wray S
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Wray S
影响因子：
11
作者：
Arber C;Toombs J;Lovejoy C;Ryan NS;Paterson RW;Willumsen N;Gkanatsiou E;Portelius E;Blennow K;Heslegrave A;Schott JM;Hardy J;Lashley T;Fox NC;Zetterberg H;Wray S
通讯作者：
Wray S
影响因子：
2.5
作者：
Armijo, Enrique;Gonzalez, Cesar;Soto, Claudio
通讯作者：
Soto, Claudio