Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).
Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).
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DOI：
10.1177/1740774510373497
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
T1DGC
中科院分区：
文献类型：
--
作者：
Hilner JE;Perdue LH;Sides EG;Pierce JJ;Wägner AM;Aldrich A;Loth A;Albret L;Wagenknecht LE;Nierras C;Akolkar B;T1DGC
背景和目的1型糖尿病遗传学联盟（T1 DGC）是一个 国际项目，其主要目的是：（a）发现基因，修改 1型糖尿病风险;和（B）扩大现有的遗传资源， 1型糖尿病的治疗最初的目标是收集2500名受影响的兄弟姐妹 全世界范围内的双（ASP）家庭。方法T1 DGC分为4个区域网络 （亚太、欧洲、北美和联合王国）和协调 中心由每个网络的代表组成的指导委员会， 协调中心和资助组织负责T1 DGC 运营协调中心与区域网络代表一起， 开发研究文件和数据系统。建立的每个网络 实验室：DNA提取和细胞系生产;人类白细胞 抗原基因分型;和自身抗体测量。样本来自 收集点，在网络实验室处理，并储存在存款 国家糖尿病、消化和肾脏疾病研究所（NIDDK） 中央储存库。收集表型数据并输入研究 数据库由协调中心管理。结果T1 DGC达到了ASP的招募目标。 在 为了应对研究设计的变化，T1 DGC基础设施也招募了 三人组、病例组和对照组。遗传分析的结果已经确定了许多 影响1型糖尿病易感性的新区域。T1 DGC创建了一个 数据和样本资源，可供研究界使用。 一些国家拒绝参加T1 DGC，原因是 在网络实验室处理样本的研究要求和/或 将样品最终存放在NIDDK中央储存库中。重新联系 参与者未被纳入知情同意模板， 收集额外样本用于功能研究。结论T1 DGC实现了分布式、区域性的网络结构 达到ASP招聘目标。事实证明，基础设施既强大又灵活 足以容纳更多的招聘。T1 DGC已经建立了重要的 为未来在1型糖尿病研究中发现提供基础的资源 糖尿病遗传学。
Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics.
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DOI：
10.1177/1740774510373492
发表时间：
2010
期刊：
Clinical trials (London, England)
影响因子：
--
作者：
Hall MA;King NM;Perdue LH;Hilner JE;Akolkar B;Greenbaum CJ;McKeon C;T1DGC
通讯作者：
T1DGC
影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
DOI：
10.1111/j.1463-1326.2008.00997.x
发表时间：
2009-02
期刊：
Diabetes, obesity & metabolism
影响因子：
--
作者：
Brown WM;Pierce J;Hilner JE;Perdue LH;Lohman K;Li L;Venkatesh RB;Hunt S;Mychaleckyj JC;Deloukas P;Type 1 Diabetes Genetics Consortium
通讯作者：
Type 1 Diabetes Genetics Consortium
DOI：
10.1016/s0197-2456(01)00179-9
发表时间：
2002-04-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Emery, S;Abrams, DI;Neaton, JD
通讯作者：
Neaton, JD
影响因子：
2.7
作者：
Rosinger, Silke;Nutland, Sarah;Steffes, Michael W.
通讯作者：
Steffes, Michael W.