Home, sweet home: how mucus accommodates our microbiota.

Home, sweet home: how mucus accommodates our microbiota.
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DOI:
10.1111/febs.15504
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发表时间:
2021-03
期刊:
The FEBS journal
影响因子:
--
通讯作者:
Ribbeck K
Ribbeck K
中科院分区:
其他
文献类型:
--
作者:
Wang BX;Wu CM;Ribbeck K

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作为人类与微生物群相互作用的自然环境,健康的粘液拥有非常稳定和多样化的微生物群落。维持这种微生物群对人类健康至关重要,既可以支持执行各种有益功能的肠道细菌,也可以防止病原体的生长。然而,宿主如何选择和维持一个专门的微生物群在很大程度上仍然是未知的。从这个角度来看,我们提出了几种策略,通过这些策略,粘液可以调节人体微生物群的组成和功能,并讨论疾病中受损的粘液屏障如何引起微生物生态失调。
As a natural environment for human-microbiota interactions, healthy mucus houses a remarkably stable and diverse microbial community. Maintaining this microbiota is essential to human health, both to support the commensal bacteria that perform a wide array of beneficial functions and to prevent the outgrowth of pathogens. However, how the host selects and maintains a specialized microbiota remains largely unknown. In this viewpoint, we propose several strategies by which mucus may regulate the composition and function of the human microbiota and discuss how compromised mucus barriers in disease can give rise to microbial dysbiosis.
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