Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.
Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.
复制标题
伏核核、前扣带皮层和杏仁核中央核的选择性兴奋性毒性损伤对大鼠自塑性能的影响。
DOI：
10.1037//0735-7044.116.4.553
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发表时间：
2002
影响因子：
1.9
通讯作者：
B. Everitt
中科院分区：
文献类型：
--
作者：
R. Cardinal;J. Parkinson;G. Lachenal;K. M. Halkerston;N. Rudarakanchana;Jeremy Hall;Caroline H. Morrison;S. Howes;T. Robbins;B. Everitt
伏隔核(ACBC)、扣带回前皮质(ACC)和杏仁中央核(CEA)是正常获得基于刺激-奖赏联系的任务所必需的。然而，尚不清楚它们是纯粹参与学习过程，还是学习反应的行为表达所必需的。大鼠在手术前接受巴甫洛夫自动整形任务的训练，在该任务中，将视觉条件刺激(CS+)与食物配对会导致受试者接近CS+，而不是接近未配对的刺激(CS-)。然后，受试者在重新测试之前接受ACBC、ACC或CEA的病变。ACBC损害严重损害了行为能力；受试者接近CS+的频率明显低于对照组，无法区分CS+和CS-。ACC损伤也损害了工作能力，但并没有完全消除歧视。CEA损伤对治疗效果无影响。因此，条件性方法反应的学习需要CEA，而不是表达，这意味着它对学习刺激-奖赏联系有特定的贡献。
The nucleus accumbens core (AcbC), anterior cingulate cortex (ACC), and central nucleus of the amygdala (CeA) are required for normal acquisition of tasks based on stimulus-reward associations. However, it is not known whether they are involved purely in the learning process or are required for behavioral expression of a learned response. Rats were trained preoperatively on a Pavlovian autoshaping task in which pairing a visual conditioned stimulus (CS+) with food causes subjects to approach the CS+ while not approaching an unpaired stimulus (CS-). Subjects then received lesions of the AcbC, ACC, or CeA before being retested. AcbC lesions severely impaired performance; lesioned subjects approached the CS+ significantly less often than controls, failing to discriminate between the CS+ and CS-. ACC lesions also impaired performance but did not abolish discrimination entirely. CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations.
杏仁核中央核和无名质/基底核的断开会破坏大鼠条件刺激处理的增量。
影响因子：
1.9
作者：
Han,JS;Holland,PC;Gallagher,M
通讯作者：
Gallagher,M
影响因子：
3.7
作者：
RAICHLE, ME;FIEZ, JA;PETERSEN, SE
通讯作者：
PETERSEN, SE