Japanese studies on neural circuits and behavior of Caenorhabditis elegans.

Japanese studies on neural circuits and behavior of Caenorhabditis elegans.
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DOI:
10.3389/fncir.2013.00187
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发表时间:
2013-11-28
影响因子:
3.5
通讯作者:
Mori I
Mori I
中科院分区:
医学3区
文献类型:
--
作者:
Sasakura H;Tsukada Y;Takagi S;Mori I

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秀丽隐杆线虫是研究神经可塑性和动物行为的理想生物。线虫雌雄同体的302个神经元被划分为118个神经元群。这个简单的神经回路为理解包括人类在内的高等动物的大脑机制提供了坚实的基础。最近的研究采用现代成像和操作技术,使研究人员能够非常精确地研究神经系统的动态特性。这种微小动物的行为和分子遗传学分析对神经回路研究的进步做出了巨大贡献。在此,我们将回顾最近在日本进行的秀丽隐杆线虫神经回路的研究。几个实验室已经建立了独特而聪明的方法来研究秀丽隐杆线虫行为调节的潜在神经元基质。应用于秀丽隐杆线虫研究的技术进步为复杂神经系统的研究提供了新的途径。通过对日本秀丽隐杆线虫神经回路研究的综述,对神经回路研究的方向进行分析和探讨。
The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the brains of higher animals, including humans. Recent studies that employ modern imaging and manipulation techniques enable researchers to study the dynamic properties of nervous systems with great precision. Behavioral and molecular genetic analyses of this tiny animal have contributed greatly to the advancement of neural circuit research. Here, we will review the recent studies on the neural circuits of C. elegans that have been conducted in Japan. Several laboratories have established unique and clever methods to study the underlying neuronal substrates of behavioral regulation in C. elegans. The technological advances applied to studies of C. elegans have allowed new approaches for the studies of complex neural systems. Through reviewing the studies on the neuronal circuits of C. elegans in Japan, we will analyze and discuss the directions of neural circuit studies.
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