ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population.
ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population.
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DOI：
10.1186/s40101-022-00312-1
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发表时间：
2022-11-05
影响因子：
3.1
通讯作者：
Kikuchi, Naoki
中科院分区：
文献类型：
--
作者：
De Almeida, Kathleen Yasmin;Saito, Mika;Homma, Hiroki;Mochizuki, Yukina;Saito, Aoto;Deguchi, Minoru;Kozuma, Ayumu;Okamoto, Takanobu;Nakazato, Koichi;Kikuchi, Naoki
关键词：
乙醛脱氢酶2（ALDH2）rs671多态性是亚洲人群独有的，与许多疾病有关。正如我们之前的研究所证明的那样，线粒体中活性氧的产生量较高，而运动员和非运动员的肌肉力量较低。本研究的目的是调查 ALDH2 rs671 对衰老过程中肌肉力量丧失的影响，并重复我们之前在非运动员中的研究。使用从唾液中提取的 DNA 对 23-94 岁的健康日本个体 (n = 1804) 进行基因分型。使用握力和椅立测试（CST）评估肌肉力量。通过根据性别、体重指数 (BMI) 和运动习惯进行调整的双向协方差分析 (ANCOVA) 来分析年龄和基因型之间的相互作用。年龄≧55岁的AA基因型个体在握力测试中的表现低于GG + GA基因型个体（28.1± 9.1 kg vs. 29.1± 8.3 kg，p= 0.021）。年龄和基因型之间存在相互作用，其中 AA 基因型≥55 岁的个体与 CST 中 GG + GA 基因型的个体相比，力量损失更高（0.025）。在其他模型中没有发现相互作用，也没有发现性别差异。这项研究重复了先前关于 AA 基因型与较低肌肉力量之间关系的结果，并且新颖地表明该基因型与年龄相关的力量损失较高有关。
The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is exclusive to the Asian population, is related to many diseases. A high reactive oxygen species production in mitochondria, and low muscle strength in athletes and non-athletes, has been observed, as our previous study demonstrated. The purpose of this research was to investigate the influence of ALDH2 rs671 on the loss of muscle strength with aging and replicate our previous study in non-athletes. Healthy Japanese individuals (n = 1804) aged 23–94 years were genotyped using DNA extracted from saliva. Muscle strength was assessed using grip strength and chair stand test (CST). The interaction between age and genotypes was analyzed by two-way analysis of covariance (ANCOVA) adjusted for sex, body mass index (BMI), and exercise habit. Individuals aged ≧55 with the AA genotype had a lower performance than those with the GG + GA genotype in the grip strength test (28.1 ± 9.1 kg vs. 29.1 ± 8.3 kg, p = 0.021). There was an interaction between age and genotype, where individuals with ≧55 years old AA genotype had a higher loss of strength compared to GG + GA genotypes in the CST (0.025). No interaction in other models and no sex differences were found. This study replicated previous results of the relationship between the AA genotype with lower muscle strength and as a novelty showed that this genotype is associated with a higher age-related loss of strength.
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影响因子：
20.1
作者：
Endo, Jin;Sano, Motoaki;Fukuda, Keiichi
通讯作者：
Fukuda, Keiichi
影响因子：
1.6
作者：
Zuo, Wei;Zhan, Zhenyu;Zeng, Shanggan
通讯作者：
Zeng, Shanggan
影响因子：
2.1
作者：
Wang D;Zou Y;Yu S;Lin S;Li H;Yin Y;Qiu L;Xu T;Wu J
通讯作者：
Wu J
影响因子：
4.6
作者：
Takeshima K;Nishiwaki Y;Suda Y;Niki Y;Sato Y;Kobayashi T;Miyamoto K;Uchida H;Inokuchi W;Tsuji T;Funayama A;Nakamura M;Matsumoto M;Toyama Y;Miyamoto T
通讯作者：
Miyamoto T
影响因子：
5.5
作者：
Jackson, Malcolm J.;McArdle, Anne
通讯作者：
McArdle, Anne