The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes.
The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes.
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DOI：
10.1186/s12872-020-01787-5
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发表时间：
2020-12-04
影响因子：
2.1
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Wang D;Zou Y;Yu S;Lin S;Li H;Yin Y;Qiu L;Xu T;Wu J
ALDH 2 rs671基因多态性与心血管疾病（CVD）有关，但缺乏全面的流行病学研究。进行了一项观察性、回顾性大数据研究，以评估中国人群中该多态性与聚集性心血管危险因素（CRF）之间的相关性。共入组13，101人（8，431名男性和4，670名女性）。使用基因突变检测试剂盒和自动荧光分析仪评估遗传多态性。其他数据来自北京协和医院卫生保健科的记录。比较ALDH 2 rs671 GG、GA和AA基因型个体之间常见生化分析物的浓度，包括BMI、SBP、DBP、ALT、AST、γ-GT、TBil、Cr、Glu、TC、TG和HDL-C，我们发现男性之间存在显著差异（所有p < 0.001），但女性之间无显著差异。对于男性，GG组的高血压、糖尿病和肥胖的发生率显著高于GA或AA组（均p < 0.05）。然而，血脂异常无显著差异，女性中所有频率均未观察到显著相关性。GG男性中具有1-4个CRF的个体的患病率显著高于携带GA或AA的个体，并且较少GG男性具有非CRF（所有p < 0.05）。ALDH 2 rs671的多态性与聚集性CRF相关，尤其是男性的高血压和糖尿病，但与女性无关。这些关联可能是由酒精摄入介导的，酒精摄入也与该基因有关。
The ALDH2 rs671 genetic polymorphism has been linked with cardiovascular diseases (CVDs), but comprehensive epidemiological studies are lacking. An observational, retrospective big data study was carried out to evaluate the associations between this polymorphism and clustering cardiovascular risk factors (CRFs) in a Chinese population. A total of 13,101 individuals (8431 males and 4670 females) were enrolled. Genetic polymorphism was assessed using gene mutation detection kits, coupled with an automatic fluorescent analyzer. Other data were obtained from the records of the Department of Health Care at Peking Union Medical College Hospital. Comparing the concentrations of common biochemical analytes, including BMI, SBP, DBP, ALT, AST, γ-GT, TBil, Cr, Glu, TC, TG, and HDL-C among individuals with the GG, GA, and AA genotypes of ALDH2 rs671, we found significant differences in males (all p < 0.001), but not in females. For males, the frequencies of hypertension, diabetes, and obesity were significantly higher for GG than for GA or AA (all p < 0.05). However, there was no significant difference for dyslipidemia, and no significant associations were observed for all frequencies in females. The prevalence of individuals with 1–4 CRFs was significantly higher among GG males than those carrying GA or AA, and fewer GG males had non-CRFs (all p < 0.05). Polymorphisms of ALDH2 rs671 are associated with clustering CRFs, especially hypertension and diabetes in males, but not in females. These associations are likely mediated by alcohol intake, which is also associated with this gene.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
低乙醇摄入对心血管系统的有益作用：可能的生化机制。
影响因子：
2.9
作者：
Vasdev, Sudesh;Gill, Vicki;Singal, Pawan K
通讯作者：
Singal, Pawan K
影响因子：
2.4
作者：
Shin MJ;Cho Y;Davey Smith G
通讯作者：
Davey Smith G
影响因子：
20.1
作者：
Endo, Jin;Sano, Motoaki;Fukuda, Keiichi
通讯作者：
Fukuda, Keiichi
影响因子：
168.9
作者：
Millwood, Iona Y.;Walters, Robin G.;Chen, Zhengming
通讯作者：
Chen, Zhengming