Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance.
Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance.
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DOI：
10.1016/j.neurobiolaging.2010.10.019
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发表时间：
2012-07
影响因子：
4.2
通讯作者：
North American Alzheimer's Disease Neuroimaging Initiative (ADNI)
中科院分区：
文献类型：
--
作者：
Ewers M;Walsh C;Trojanowski JQ;Shaw LM;Petersen RC;Jack CR Jr;Feldman HH;Bokde AL;Alexander GE;Scheltens P;Vellas B;Dubois B;Weiner M;Hampel H;North American Alzheimer's Disease Neuroimaging Initiative (ADNI)
目前的研究测试了主要MRI和脑脊液（CSF）生物标志物候选者和神经心理学测试的准确性，以预测从轻度认知障碍（MCI）到阿尔茨海默病（AD）痴呆的转换。在交叉验证范例中，在AD（N = 81）和老年对照受试者（N = 101）的训练集中估计预测模型。CSF t-tau/Aβ1-4比值和MRI生物标志物或神经心理学测试（自由回忆和连线测试B（TMT-B））的组合显示AD与HC比较的最佳统计学拟合，当应用于MCI转换的预测时，分类准确度高达64%（3.3年观察间隔，平均= 2.3年）。然而，几个单预测模型显示MCI转换的预测准确性与任何多预测模型相当。最佳单一预测因子为右侧内嗅皮质（预测准确率= 68.5%（95%CI（59.5，77.4）和TMT-B测试（预测准确率64.6%（95%CI（55.5，73.4%）。总之，在遗忘型MCI受试者中，单标志物模型预测短期转换为AD的程度与多标志物模型相当。
The current study tested the accuracy of primary MRI and cerebrospinal fluid (CSF) biomarker candidates and neuropsychological tests for predicting the conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. In a cross-validation paradigm, predictor models were estimated in the training set of AD (N = 81) and elderly control subjects (N = 101). A combination of CSF t-tau/Aβ1-4 ratio and MRI biomarkers or neuropsychological tests (free recall and trail making test B (TMT-B)) showed the best statistical fit in the AD vs. HC comparison, reaching a classification accuracy of up to 64% when applied to the prediction of MCI conversion (3.3-year observation interval, mean = 2.3 years). However, several single-predictor models showed a predictive accuracy of MCI conversion comparable to that of any multipredictor model. The best single predictors were right entorhinal cortex (prediction accuracy = 68.5% (95% CI (59.5, 77.4))) and TMT-B test (prediction accuracy 64.6% (95% CI (55.5, 73.4%))). In conclusion, short-term conversion to AD is predicted by single marker models to a comparable degree as by multimarker models in amnestic MCI subjects.
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影响因子：
9.9
作者：
Ewers, M.;Buerger, K.;Hampel, H.
通讯作者：
Hampel, H.
在早期发现阿尔茨海默氏病时，磁共振成像可改善脑脊液生物标志物。
DOI：
10.3233/jad-2009-0968
发表时间：
2009
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Brys M;Glodzik L;Mosconi L;Switalski R;De Santi S;Pirraglia E;Rich K;Kim BC;Mehta P;Zinkowski R;Pratico D;Wallin A;Zetterberg H;Tsui WH;Rusinek H;Blennow K;de Leon MJ
通讯作者：
de Leon MJ
影响因子：
9.9
作者：
Herukka, SK;Hallikainen, M;Pirttilä, T
通讯作者：
Pirttilä, T
影响因子：
9.9
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E