The selective dopamine D3 receptor antagonist SB-277011A significantly accelerates extinction to environmental cues associated with cocaine-induced place preference in male Sprague-Dawley rats.
The selective dopamine D3 receptor antagonist SB-277011A significantly accelerates extinction to environmental cues associated with cocaine-induced place preference in male Sprague-Dawley rats.
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DOI：
10.1002/syn.21839
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Gardner EL
中科院分区：
文献类型：
--
作者：
Ashby CR Jr;Rice OV;Heidbreder CA;Gardner EL
啮齿类动物的再暴露（Shaham等人，2003），以及人类成瘾者（Epstein等人，2006），与各种药物滥用相关的环境线索产生或激发药物寻求行为。灭绝已被用于减少人类和动物对药物的条件反应。消退是一种主动学习过程，在没有先前与CS配对的非条件刺激（UCS）（例如成瘾药物或食欲刺激）的情况下，条件刺激（CS）（例如环境线索）的重复呈现会减弱对CS的反应幅度或频率（Myers和Carlezon，2010）。减少消退所需时间的治疗或行为改变可能有助于减少人类成瘾者的线索诱导的药物寻求行为。在大鼠中，急性施用高选择性多巴胺D3受体拮抗剂SB-277011 A（Heidbreder等人，2005）显著减弱了对可卡因、海洛因和尼古丁的条件性位置偏好（CPP）的表达（Heidbreder和纽曼，2010）。在本研究中，我们确定了SB-277011 A ip给药是否有助于大鼠中可卡因诱导的CPP的消退。所有实验均使用了幼稚的雄性Sprague-Dawley大鼠（CPP配对开始时为190-210克，Taconic Farms，日耳曼敦，纽约州）。动物如前所述圈养、饲养、喂食和饮水（Ashby et al.，2015）。所有动物的调节和测试均在1100至1800小时之间进行。如前所述使用自动化的双室树脂玻璃CPP装置（Ashby等人，2015年，修改。对所有动物进行驯化，运输至实验室，处理并给予
The re-exposure of rodents (Shaham et al., 2003), as well as human addicts (Epstein et al., 2006), to environmental cues associated with various drugs of abuse produces or elicits drug-seeking behavior. Extinction has been used to reduce conditioned responses to drugs in humans and animals. Extinction is an active learning process, where repetitive presentations of conditioned stimuli (CS)(eg environmental cues) in the absence of the unconditioned stimulus (UCS)(eg addictive drug or appetitive stimuli) previously paired with the CS weakens the magnitude or frequency of response to the CS (Myers and Carlezon, 2010). Treatments or behavioral modifications that reduce the time required for extinction could be useful in decreasing cue-induced drug seeking behavior in human addicts. In rats, acute administration of the highly selective dopamine D3 receptor antagonist SB-277011A (Heidbreder et al., 2005) significantly attenuates the expression of conditioned place preference (CPP) to cocaine, heroin and nicotine (Heidbreder and Newman, 2010). In this study, we determined whether ip administration of SB-277011A facilitates extinction of cocaine-induced CPP in rats.Naïve, male Sprague-Dawley rats (190-210 grams at the start of CPP pairings, Taconic Farms, Germantown, NY) were used in all experiments. Animals were housed, maintained, fed, and watered as previously described (Ashby et al., 2015). The conditioning and testing of all animals was carried out between 1100 and 1800 h. An automated, two-chambered, Plexiglas CPP apparatus was used as previously described (Ashby et al., 2015), with modifications. All animals were acclimated, transported to the laboratory, handled and given
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影响因子：
8.2
作者：
Myers, Karyn M.;Carlezon, William A., Jr.
通讯作者：
Carlezon, William A., Jr.
影响因子：
5.2
作者：
Heidbreder CA;Newman AH
通讯作者：
Newman AH
影响因子：
4.7
作者：
Song R;Bi GH;Zhang HY;Yang RF;Gardner EL;Li J;Xi ZX
通讯作者：
Xi ZX
DOI：
10.1111/j.1460-9568.2009.07027.x
发表时间：
2009-11
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Aragona BJ;Day JJ;Roitman MF;Cleaveland NA;Wightman RM;Carelli RM
通讯作者：
Carelli RM
影响因子：
4.7
作者：
Millan, Mark J.;Di Cara, Benjamin;Gobert, Alain
通讯作者：
Gobert, Alain