BEST1 Positive Monocytes in Circulation: Visualize Intratumoral Crosstalk between Cancer Cells and Monocytes.
BEST1 Positive Monocytes in Circulation: Visualize Intratumoral Crosstalk between Cancer Cells and Monocytes.
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DOI：
10.1002/advs.202205915
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发表时间：
2023-06
期刊：
影响因子：
--
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中科院分区：
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头颈鳞状细胞癌 (HNSCC) 的特点是从外周血中招募大量单核细胞和巨噬细胞。然而，尚未确定这些浸润细胞是否可以释放回循环并具有肿瘤相关的新生物特征。本研究报告，Bestropin1 (BEST1) 是 Ca2+ 激活的 Cl− 通道 (CaCC) 的一种组成蛋白，在 HNSCC 患者外周血的经典单核细胞中高度表达。这是由于肿瘤细胞对单核细胞的教育，其中肿瘤 VEGF-A 通过 MEK-ERK-ELK1 途径上调单核细胞上的 BEST1 表达。这导致 IL-6 和 IL-8 的分泌增加，从而促进肿瘤细胞增殖。这项工作还发现 BEST1 促进单核细胞的运动，有助于这些细胞迁移回循环。这些结果表明，外周单核细胞上 BEST1 的表达可能是监测肿瘤进展的潜在工具，并开辟了在单核细胞而不是肿瘤或其产物上寻找癌症生物标志物的可能性。在头颈鳞状细胞癌患者中，单核细胞上的 Bestropin1 表达升高，可能作为肿瘤进展的潜在生物标志物。肿瘤细胞通过 VEGF-A 进行单核细胞教育也增强了 IL-6 和 IL-8 的分泌，促进肿瘤细胞增殖。
Head and neck squamous cell carcinomas (HNSCCs) are characterized by an abundance of monocytes and macrophages recruited from the peripheral blood. However, it has not been determined whether these infiltrated cells can be released back into circulation with a tumor‐associated neobiosignature. This study reports that Bestrophin1 (BEST1), a component protein of Ca2+‐activated Cl− channels (CaCCs), is highly expressed on classical monocytes in the peripheral blood of HNSCC patients. This is due to monocyte education by tumor cells, in which tumoral VEGF‐A upregulates BEST1 expression on monocytes through the MEK‐ERK‐ELK1 pathway. This leads to improved secretion of IL‐6 and IL‐8, which promotes tumor cell proliferation. This work also finds that BEST1 facilitates the motility of monocytes, contributing to the migration of these cells back into circulation. These results suggest that the expression of BEST1 on peripheral monocytes may be a potential tool for monitoring tumor progression, and opens up the possibility of searching for cancer biomarkers on monocytes rather than on the tumor or its products. Bestrophin1 expression on monocytes is elevated in head and neck squamous cell carcinoma patients and may serve as a potential biomarker for tumor progression. Monocyte education by tumor cells through VEGF‐A also enhances secretion of IL‐6 and IL‐8, promoting tumor cell proliferation.
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影响因子：
5.6
作者：
Coy JF
通讯作者：
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影响因子：
5.3
作者：
Czepluch, Frauke S.;Olieslagers, Serve;Waltenberger, Johannes
通讯作者：
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影响因子：
64.5
作者：
Lam KC;Araya RE;Huang A;Chen Q;Di Modica M;Rodrigues RR;Lopès A;Johnson SB;Schwarz B;Bohrnsen E;Cogdill AP;Bosio CM;Wargo JA;Lee MP;Goldszmid RS
通讯作者：
Goldszmid RS
肿瘤相关巨噬细胞的细胞和分子起源。
DOI：
10.1126/science.1252510
发表时间：
2014-05-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Franklin RA;Liao W;Sarkar A;Kim MV;Bivona MR;Liu K;Pamer EG;Li MO
通讯作者：
Li MO
影响因子：
2.3
作者：
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