Detection of Tioman Virus in Pteropus vampyrus Near Flores, Indonesia.
Detection of Tioman Virus in Pteropus vampyrus Near Flores, Indonesia.
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DOI：
10.3390/v13040563
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发表时间：
2021-03-26
期刊：
影响因子：
--
通讯作者：
Mendenhall IH
中科院分区：
文献类型：
--
作者：
Tsang SM;Low DHW;Wiantoro S;Smith I;Jayakumar J;Simmons NB;Vijaykrishna D;Lohman DJ;Mendenhall IH
多种副粘病毒与蝙蝠宿主共同进化，包括果蝠如狐蝠（翼手目：狐蝠科）。这些病毒中有几种是人畜共患病毒，但副粘病毒科的多样性和分布知之甚少。我们筛选合并的粪便样本从三个狐蝠vampyrus殖民地和分析组织，直肠拭子，口腔拭子从95个人的23个pteropodid物种在17个地点在印度尼西亚群岛与传统的副粘病毒PCR采样;所有测试阴性。来自43个个体的样本用下一代测序（NGS）进行筛选，并且在弗洛雷斯附近收集的单个Pteropus vampyrus具有Tioman病毒测序读数。Tioman病毒是一种蝙蝠传播的病毒，属于副红细胞病毒属，先前有证据表明它会扩散到人类。这项工作扩大了Tioman病毒的已知范围，很可能这个孤立的殖民地可能在很长一段时间内持续了代际传播。
Diverse paramyxoviruses have coevolved with their bat hosts, including fruit bats such as flying foxes (Chiroptera: Pteropodidae). Several of these viruses are zoonotic, but the diversity and distribution of Paramyxoviridae are poorly understood. We screened pooled feces samples from three Pteropus vampyrus colonies and assayed tissues, rectal swabs, and oral swabs from 95 individuals of 23 pteropodid species sampled at 17 sites across the Indonesian archipelago with a conventional paramyxovirus PCR; all tested negative. Samples from 43 individuals were screened with next generation sequencing (NGS), and a single Pteropus vampyrus collected near Flores had Tioman virus sequencing reads. Tioman virus is a bat-borne virus in the genus Pararubulavirus with prior evidence of spillover to humans. This work expands the known range of Tioman virus, and it is likely that this isolated colony likely has sustained intergenerational transmission over a long period.
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