Specifying neural crest cells: From chromatin to morphogens and factors in between.
Specifying neural crest cells: From chromatin to morphogens and factors in between.
复制标题
DOI：
10.1002/wdev.322
复制
发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Nie S
中科院分区：
文献类型：
--
作者：
Rogers CD;Nie S
神经嵴（NC）细胞是存在于脊椎动物胚胎中的干细胞样多能祖细胞群，可迁移至发育中的生物体的各个区域。这些细胞被称为“第四胚层”，起源于神经板（NP）和非神经组织之间的外胚层，神经板将成为大脑和脊髓，非神经组织将成为皮肤和感觉器官。NC细胞可以响应于适当的信号分化成超过30种不同的衍生物，包括但不限于颅面骨和软骨、感觉神经和神经节、色素细胞和结缔组织。控制NC细胞的诱导和特化的分子和细胞机制包括表观遗传控制、多个相互作用和冗余的转录途径、分泌的信号分子和粘附分子。NC细胞是重要的，不仅因为它们转化成各种各样的组织类型，而且因为它们从上皮邻居分离并在整个发育胚胎中迁移的能力利用了与转移性癌细胞相似的机制。在这篇综述中，我们讨论了NC细胞在各种脊椎动物物种中的诱导和规范所需的机制，重点是早期形态发生，细胞粘附，邻近组织的信号传导，以及控制这些惊人细胞形成的大量转录网络的作用。神经系统发育>脊椎动物：一般原则基因表达和转录层次>调控机制基因表达和转录层次>基因网络和基因组学信号通路>细胞命运信号这篇文章分类下：
Neural crest (NC) cells are a stem-like multipotent population of progenitor cells that are present in vertebrate embryos, traveling to various regions in the developing organism. Known as the “fourth germ layer”, these cells originate in the ectoderm between the neural plate (NP), which will become the brain and spinal cord, and nonneural tissues that will become the skin and the sensory organs. NC cells can differentiate into more than 30 different derivatives in response to the appropriate signals including, but not limited to, craniofacial bone and cartilage, sensory nerves and ganglia, pigment cells, and connective tissue. The molecular and cellular mechanisms that control the induction and specification of NC cells include epigenetic control, multiple interactive and redundant transcriptional pathways, secreted signaling molecules, and adhesion molecules. NC cells are important not only because they transform into a wide variety of tissue types, but also because their ability to detach from their epithelial neighbors and migrate throughout developing embryos utilizes mechanisms similar to those used by metastatic cancer cells. In this review, we discuss the mechanisms required for the induction and specification of NC cells in various vertebrate species, focusing on the roles of early morphogenesis, cell adhesion, signaling from adjacent tissues, and the massive transcriptional network that controls the formation of these amazing cells. Nervous System Development > Vertebrates: General Principles Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms Gene Expression and Transcriptional Hierarchies > Gene Networks and Genomics Signaling Pathways > Cell Fate Signaling This article is categorized under:
登录
查看更多内容
影响因子：
2.7
作者：
Aruga, J;Tohmonda, T;Mikoshiba, K
通讯作者：
Mikoshiba, K
影响因子：
2.7
作者：
Bonano, Marcela;Tribulo, Celeste;Aybar, Manuel J.
通讯作者：
Aybar, Manuel J.
影响因子：
64.8
作者：
Abitua, Philip Barron;Wagner, Eileen;Navarrete, Ignacio A.;Levine, Michael
通讯作者：
Levine, Michael
DOI：
10.1007/7651_2015_234
发表时间：
2016-01-01
期刊：
EMBRYONIC STEM CELL PROTOCOLS
影响因子：
--
作者：
Avery, John;Dalton, Stephen
通讯作者：
Dalton, Stephen
影响因子：
2.5
作者：
Bell, GW;Yatskievych, TA;Antin, PB
通讯作者：
Antin, PB