Physiological roles for mafr-1 in reproduction and lipid homeostasis.
Physiological roles for mafr-1 in reproduction and lipid homeostasis.
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DOI：
10.1016/j.celrep.2014.11.035
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发表时间：
2014-12-24
期刊：
影响因子：
8.8
通讯作者：
Curran SP
中科院分区：
文献类型：
--
作者：
Khanna A;Johnson DL;Curran SP
Maf1 is a conserved repressor of RNA polymerase (pol) III transcription; however, its physiological role in the context of a multicellular organism is not well understood. Here, we show that C. elegans MAFR-1 is functionally orthologous to human Maf1, represses the expression of both RNA pol III and pol II transcripts, and mediates organismal fecundity and lipid homeostasis. MAFR-1 impacts lipid transport by modulating intestinal expression of the vitellogenin family of proteins, resulting in cell non-autonomous defects in the developing reproductive system. MAFR-1 levels inversely correlate with stored intestinal lipids, in part by influencing the expression of the lipogenesis enzymes fasn-1/FASN and pod-2/ACC1. Animals fed a high carbohydrate diet exhibit reduced mafr-1 expression and mutations in the insulin signaling pathway genes daf-18/PTEN and daf-16/FoxO abrogate the lipid storage defects associated with deregulated mafr-1 expression. Our results reveal physiological roles for mafr-1 in regulating organismal lipid homeostasis, which ensure reproductive success.
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影响因子：
16
作者：
Kaltenbach, L;Horner, MA;Mango, SE
通讯作者：
Mango, SE
影响因子：
3.7
作者：
Brooks KK;Liang B;Watts JL
通讯作者：
Watts JL
秀丽隐杆线虫中不饱和脂肪酸组成的遗传调节。
影响因子：
4.5
作者：
Brock, Trisha J.;Browse, John;Watts, Jennifer L.
通讯作者：
Watts, Jennifer L.
MAF1是PTEN和PI3K信号的新靶标，可负调节肿瘤发生和脂质代谢。
影响因子：
4.5
作者：
Palian BM;Rohira AD;Johnson SA;He L;Zheng N;Dubeau L;Stiles BL;Johnson DL
通讯作者：
Johnson DL
影响因子：
14.9
作者：
KINSEY, PT;SANDMEYER, SB
通讯作者：
SANDMEYER, SB