Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in schizophrenia.
Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in schizophrenia.
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DOI：
10.1016/j.neuropsychologia.2011.06.009
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发表时间：
2011-08
期刊：
影响因子：
2.6
通讯作者：
MacDonald AW 3rd
中科院分区：
文献类型：
--
作者：
Kang SS;Sponheim SR;Chafee MV;MacDonald AW 3rd
虽然已经确定了精神分裂症中空间工作记忆（SWM）缺陷背后的区域大脑异常，但对于精神分裂症中哪些脑回路在空间工作记忆网络中功能中断知之甚少。我们利用功能性磁共振成像（fMRI）数据研究了精神分裂症中swm相关的区域间功能连通性，这些数据是在需要分析物体结构空间信息的记忆任务中收集的。12名精神分裂症患者和11名正常对照。在SWM高负荷条件下，患者表现出SWM功能缺陷和大脑各区域神经激活不足。对SWM任务引起的区域脑激活的共变检查揭示了精神分裂症患者前额叶和后叶视觉关联区之间功能断开的证据。在低SMW负荷下，我们发现患者右半球背外侧前额叶皮层（DLPFC）和下颞叶皮层（ITC）之间的功能关联减少。在高SWM负荷下，我们发现了患者进一步功能断开的证据，包括左侧DLPFC与右侧视觉区域（包括后顶叶皮层（PPC）、梭状回和V1）以及右侧额下叶皮层与右侧PPC之间的功能关联进一步减少。在对照组中，更大的前额-后皮层功能连通性与更好的SWM表现相关，但在患者中没有。这些结果表明，与视觉信息的维持和控制相关的前额-后部功能连接是SWM的核心，而这种功能网络的破坏是精神分裂症SWM缺陷的基础。
Although regional brain abnormalities underlying spatial working memory (SWM) deficits in schizophrenia have been identified, little is known about which brain circuits are functionally disrupted in the SWM network in schizophrenia. We investigated SWM-related interregional functional connectivity in schizophrenia using functional magnetic resonance imaging (fMRI) data collected during a memory task that required analysis of spatial information in object structure. Twelve schizophrenia patients and eleven normal control subjects participated. Patients had SWM performance deficits and deficient neural activation in various brain areas, especially in the high SWM load condition. Examination of the covariation of regional brain activations elicited by the SWM task revealed evidence of functional disconnection between prefrontal and posterior visual association areas in schizophrenia. Under low SMW load, we found reduced functional associations between dorsolateral prefrontal cortex (DLPFC) and inferior temporal cortex (ITC) in the right hemisphere in patients. Under high SWM load, we found evidence for further functional disconnection in patients, including additional reduced functional associations between left DLPFC and right visual areas, including the posterior parietal cortex (PPC), fusiform gyrus, and V1, as well as between right inferior frontal cortex and right PPC. Greater prefrontal-posterior cortical functional connectivity was associated with better SWM performance in controls, but not in patients. These results suggest that prefrontal-posterior functional connectivity associated with the maintenance and control of visual information is central to SWM, and that disruption of this functional network underlies SWM deficits in schizophrenia.
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影响因子：
17.7
作者：
Conklin, HM;Curtis, CE;Iacono, WG
通讯作者：
Iacono, WG
影响因子：
3.6
作者：
BLACK, FW;STRUB, RL
通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
SERVANSCHREIBER, D
影响因子：
5.7
作者：
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通讯作者：
Fonlupt, Pierre
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y