A prenatal programming perspective on the intergenerational transmission of maternal adverse childhood experiences to offspring health problems.
A prenatal programming perspective on the intergenerational transmission of maternal adverse childhood experiences to offspring health problems.
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从产前规划角度看母亲不良童年经历对后代健康问题的代际传递。
DOI：
10.1037/amp0000762
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Winstone LK
中科院分区：
文献类型：
--
作者：
Roubinov DS;Luecken LJ;Curci SG;Somers JA;Winstone LK
几十年的研究表明，童年经历逆境的人在一生中都有身体和心理健康状况不佳的风险。最近，创伤的代际传播和产前规划框架表明，不良童年经历（ace）的影响范围更广，其后果会延伸到后代。除了经验研究中典型观察到的个人层面的后果之外，母亲早期的逆境经历也可能损害母子二元关系。我们提出了一个概念模型，即母亲的ace通过提高围产期社会心理风险影响母婴二元功能和后来的生物行为健康结果。我们用Las Madres Nuevas的数据为模型中提出的路径和机制过程提供支持，Las Madres Nuevas是一项对低收入墨西哥裔家庭进行的纵向研究，这些家庭从产前到幼儿期参加了一系列的家庭和实验室访问。在Las Madres Nuevas参与者中，较高的ace暴露与许多围产期社会心理风险因素相关，这预示着较差的母婴双元功能。婴儿期双重功能受损与后来的母亲心理健康和儿童行为问题有关。最后，我们讨论了预防和治疗策略，可以缓冲提出的风险途径，包括围产期评估产妇ace和社会心理风险，围产期治疗产妇窘迫，以及产后母婴治疗。我们希望所提出的概念模型将作为未来研究的指南，以检查高风险人群内和跨代的童年逆境的持久后果。
Decades of research indicate that individuals exposed to childhood adversity are at risk for poor physical and mental health across their lifespan. More recently, intergenerational transmission of trauma and prenatal programming frameworks suggest an even longer reach for adverse childhood experiences (ACEs), with consequences that extend to subsequent generations. Beyond the individual-level consequences typically observed by empirical studies of ACEs, mothers’ experiences of early adversity may also compromise the maternal-child dyadic relationship. We propose a conceptual model whereby mothers’ ACEs impact maternal-infant dyadic functioning and later biobehavioral health outcomes through heightened perinatal psychosocial risk. We provide support for the proposed paths and mechanistic processes in our model with data drawn from Las Madres Nuevas, a longitudinal study of low-income Mexican-origin families who participated in a series of home and laboratory visits from the prenatal period through early childhood. Higher ACEs exposure among Las Madres Nuevas participants was associated with numerous perinatal psychosocial risk factors, which predicted poorer mother-infant dyadic functioning. Compromised dyadic functioning during infancy was associated with later maternal mental health and child behavior problems. We conclude with discussion of prevention and treatment strategies that can buffer against proposed risk pathways, including perinatal assessment of maternal ACEs and psychosocial risk, perinatal treatment of maternal distress, and mother-infant therapy in the postpartum period. It is our hope that the proposed conceptual model will serve as a guide for future research to examine the lasting consequences of childhood adversities within and across generations among high-risk populations.
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影响因子：
6.9
作者：
Brugha, T. S.;Morrell, C. J.;Slade, P.;Walters, S. J.
通讯作者：
Walters, S. J.
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.7
作者：
Davis, Elysia Poggi;Sandman, Curt A.
通讯作者：
Sandman, Curt A.
DOI：
10.1080/01674820802546220
发表时间：
2008-12
期刊：
Journal of psychosomatic obstetrics and gynaecology
影响因子：
--
作者：
DiPietro JA;Christensen AL;Costigan KA
通讯作者：
Costigan KA
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L